STRINGSTRING
DLD DLD FBP2 FBP2 PCK1 PCK1 PKLR PKLR G6PC3 G6PC3 INS INS LOC102169935 LOC102169935 G6PC2 G6PC2 GOT2 GOT2 PDK4 PDK4 GOT1L1 GOT1L1 PKM PKM GPT GPT G6PC G6PC GPT2 GPT2 PCK2 PCK2 GOT1 GOT1 PC PC DLAT DLAT LEP LEP ALB ALB IGF1 IGF1 TAT TAT FOXO1 FOXO1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DLDDihydrolipoyl dehydrogenase. (509 aa)
FBP2Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family. (350 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (575 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
LOC102169935Uncharacterized protein; Belongs to the arylamine N-acetyltransferase family. (290 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
GOT2Aspartate aminotransferase. (430 aa)
PDK4Protein-serine/threonine kinase. (407 aa)
GOT1L1Glutamic-oxaloacetic transaminase 1 like 1. (404 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (531 aa)
GPTGlutamic--pyruvic transaminase. (496 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
GPT2Glutamic--pyruvic transaminase 2. (523 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa)
GOT1Aspartate aminotransferase. (413 aa)
PCPyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1187 aa)
DLATAcetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (647 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa)
ALBSerum albumin. (608 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (188 aa)
TATTyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (447 aa)
FOXO1Forkhead box O1. (668 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
Server load: low (18%) [HD]