33 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	LOC106501717	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	PPARA	Peroxisome proliferator activated receptor alpha. (470 aa)
	ND4L	NADH-ubiquinone oxidoreductase chain 4L; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (98 aa)
	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (159 aa)
	SRC	Tyrosine-protein kinase. (538 aa)
	TBP	Uncharacterized protein. (327 aa)
	LOC102168954	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (219 aa)
	SDHC	Succinate dehydrogenase complex subunit C. (169 aa)
	SOD2	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
	XPA	XPA, DNA damage recognition and repair factor. (273 aa)
	ATP5F1B	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (528 aa)
	SIRT1	Deacetylase sirtuin-type domain-containing protein. (732 aa)
	NRF1	Nuclear respiratory factor 1. (503 aa)
	SDHB	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (280 aa)
	ACTB	Uncharacterized protein. (375 aa)
	LMNB2	Lamin B2; Belongs to the intermediate filament family. (641 aa)
	NDUFS1	NADH:ubiquinone oxidoreductase core subunit S1; Belongs to the complex I 75 kDa subunit family. (727 aa)
	SIRT3	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (333 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3058 aa)
	UCP2	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
	NDUFS3	NADH:ubiquinone oxidoreductase core subunit S3; Belongs to the complex I 30 kDa subunit family. (266 aa)
	SDHA	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (665 aa)
	CETN2	Centrin 2. (166 aa)
	NOX1	NADPH oxidase 1. (498 aa)
	GPX6	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (223 aa)
	ENSCHIP00000023849	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (177 aa)
	MFN1	Mitofusin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (747 aa)
	OGG1	8-oxoguanine DNA glycosylase. (345 aa)
	GPX8	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (209 aa)
	GPX7	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (186 aa)
	NDUFS4	NADH:ubiquinone oxidoreductase subunit S4. (175 aa)
	TUBB	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (444 aa)
	LOC102173997	Capra hircus breed Kapro cytochrome c mRNA; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ATM	ENSCHIP00000011080	ENSCHIP00000016363	Uncharacterized protein.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.762
ACTB	ATP5F1B	ENSCHIP00000011080	ENSCHIP00000007152	Uncharacterized protein.	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.633
ACTB	CETN2	ENSCHIP00000011080	ENSCHIP00000020516	Uncharacterized protein.	Centrin 2.	0.427
ACTB	ENSCHIP00000023849	ENSCHIP00000011080	ENSCHIP00000023849	Uncharacterized protein.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.718
ACTB	GPX6	ENSCHIP00000011080	ENSCHIP00000020908	Uncharacterized protein.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.704
ACTB	GPX7	ENSCHIP00000011080	ENSCHIP00000029981	Uncharacterized protein.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.717
ACTB	GPX8	ENSCHIP00000011080	ENSCHIP00000026386	Uncharacterized protein.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.717
ACTB	LMNB2	ENSCHIP00000011080	ENSCHIP00000011094	Uncharacterized protein.	Lamin B2; Belongs to the intermediate filament family.	0.871
ACTB	LOC102168954	ENSCHIP00000011080	ENSCHIP00000004343	Uncharacterized protein.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.716
ACTB	LOC102173997	ENSCHIP00000011080	ENSCHIP00000031546	Uncharacterized protein.	Capra hircus breed Kapro cytochrome c mRNA; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.884
ACTB	LOC106501717	ENSCHIP00000011080	ENSCHIP00000032023	Uncharacterized protein.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.884
ACTB	MFN1	ENSCHIP00000011080	ENSCHIP00000024001	Uncharacterized protein.	Mitofusin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.637
ACTB	NOX1	ENSCHIP00000011080	ENSCHIP00000020812	Uncharacterized protein.	NADPH oxidase 1.	0.673
ACTB	NRF1	ENSCHIP00000011080	ENSCHIP00000008463	Uncharacterized protein.	Nuclear respiratory factor 1.	0.564
ACTB	OGG1	ENSCHIP00000011080	ENSCHIP00000026279	Uncharacterized protein.	8-oxoguanine DNA glycosylase.	0.431
ACTB	PPARA	ENSCHIP00000011080	ENSCHIP00000032439	Uncharacterized protein.	Peroxisome proliferator activated receptor alpha.	0.681
ACTB	SDHA	ENSCHIP00000011080	ENSCHIP00000018522	Uncharacterized protein.	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).	0.726
ACTB	SDHB	ENSCHIP00000011080	ENSCHIP00000011037	Uncharacterized protein.	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).	0.571
ACTB	SIRT1	ENSCHIP00000011080	ENSCHIP00000007571	Uncharacterized protein.	Deacetylase sirtuin-type domain-containing protein.	0.852
ACTB	SIRT3	ENSCHIP00000011080	ENSCHIP00000014223	Uncharacterized protein.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.670