23 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FOXA2	Forkhead box A2. (467 aa)
	ERRFI1	ERBB receptor feedback inhibitor 1. (460 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (596 aa)
	FOXO1	Forkhead box O1. (668 aa)
	ELK4	ETS transcription factor ELK4. (432 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
	MCM3	DNA helicase; Belongs to the MCM family. (808 aa)
	AR	Androgen receptor. (891 aa)
	CAMKK2	Calcium/calmodulin dependent protein kinase kinase 2. (594 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	FOXA1	Forkhead box A1. (468 aa)
	TMPRSS2	Transmembrane serine protease 2; Belongs to the peptidase S1 family. (492 aa)
	EAF2	ELL associated factor 2. (262 aa)
	GNMT	Glycine N-methyltransferase. (295 aa)
	HOXB13	Homeobox B13. (285 aa)
	SOCS2	Suppressor of cytokine signaling 2. (198 aa)
	EZH2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
	HOXD13	Homeobox D13. (340 aa)
	ACTB	Uncharacterized protein. (375 aa)
	ETV1	ETS variant 1. (477 aa)
	RAD50	Zinc-hook domain-containing protein. (1332 aa)
	CTCF	CCCTC-binding factor. (727 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	AR	ENSCHIP00000011080	ENSCHIP00000024342	Uncharacterized protein.	Androgen receptor.	0.792
ACTB	CTCF	ENSCHIP00000011080	ENSCHIP00000011578	Uncharacterized protein.	CCCTC-binding factor.	0.523
ACTB	ESR1	ENSCHIP00000011080	ENSCHIP00000012243	Uncharacterized protein.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.859
ACTB	EZH2	ENSCHIP00000011080	ENSCHIP00000003420	Uncharacterized protein.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.696
ACTB	FOXA1	ENSCHIP00000011080	ENSCHIP00000027706	Uncharacterized protein.	Forkhead box A1.	0.421
ACTB	FOXA2	ENSCHIP00000011080	ENSCHIP00000011890	Uncharacterized protein.	Forkhead box A2.	0.541
ACTB	FOXO1	ENSCHIP00000011080	ENSCHIP00000018991	Uncharacterized protein.	Forkhead box O1.	0.791
ACTB	GAPDH	ENSCHIP00000011080	ENSCHIP00000025974	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.979
ACTB	LEP	ENSCHIP00000011080	ENSCHIP00000021235	Uncharacterized protein.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]	0.846
ACTB	MTOR	ENSCHIP00000011080	ENSCHIP00000021872	Uncharacterized protein.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.734
ACTB	TMPRSS2	ENSCHIP00000011080	ENSCHIP00000029298	Uncharacterized protein.	Transmembrane serine protease 2; Belongs to the peptidase S1 family.	0.593
AR	ACTB	ENSCHIP00000024342	ENSCHIP00000011080	Androgen receptor.	Uncharacterized protein.	0.792
AR	ESR1	ENSCHIP00000024342	ENSCHIP00000012243	Androgen receptor.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.767
AR	ETV1	ENSCHIP00000024342	ENSCHIP00000009235	Androgen receptor.	ETS variant 1.	0.665
AR	EZH2	ENSCHIP00000024342	ENSCHIP00000003420	Androgen receptor.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.786
AR	FOXA1	ENSCHIP00000024342	ENSCHIP00000027706	Androgen receptor.	Forkhead box A1.	0.935
AR	FOXA2	ENSCHIP00000024342	ENSCHIP00000011890	Androgen receptor.	Forkhead box A2.	0.653
AR	FOXO1	ENSCHIP00000024342	ENSCHIP00000018991	Androgen receptor.	Forkhead box O1.	0.673
AR	GAPDH	ENSCHIP00000024342	ENSCHIP00000025974	Androgen receptor.	Glyceraldehyde-3-phosphate dehydrogenase.	0.792
AR	HOXB13	ENSCHIP00000024342	ENSCHIP00000032940	Androgen receptor.	Homeobox B13.	0.662