STRINGSTRING
ATG4B ATG4B VAMP7 VAMP7 JUN JUN ATG4A ATG4A VAMP2 VAMP2 IL6 IL6 ATG3 ATG3 RHOA RHOA TSC2 TSC2 SOD1 SOD1 ATG13 ATG13 GABARAPL2 GABARAPL2 ATG14 ATG14 BCL2 BCL2 VAMP8 VAMP8 AMBRA1 AMBRA1 ATG101 ATG101 SNAP29 SNAP29 ATG7 ATG7 SCRIB SCRIB ATG5 ATG5 GABARAP GABARAP BECN1 BECN1 MAF MAF ATG10 ATG10 ATG12 ATG12 ATG9B ATG9B UVRAG UVRAG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ATG4BCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (376 aa)
VAMP7Vesicle associated membrane protein 7; Belongs to the synaptobrevin family. (220 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
ATG4ACysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (409 aa)
VAMP2V-SNARE coiled-coil homology domain-containing protein. (116 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
ATG3Uncharacterized protein. (158 aa)
RHOARas-like protein family member A. (193 aa)
TSC2Rap-GAP domain-containing protein. (1817 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
ATG13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (517 aa)
GABARAPL2Uncharacterized protein. (117 aa)
ATG14Autophagy related 14. (492 aa)
BCL2BH4_2 domain-containing protein. (229 aa)
VAMP8Vesicle associated membrane protein 8. (101 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1300 aa)
ATG101Autophagy related 101. (218 aa)
SNAP29Synaptosome associated protein 29. (258 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (722 aa)
SCRIBScribble planar cell polarity protein. (1582 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
GABARAPGABA type A receptor-associated protein. (117 aa)
BECN1Uncharacterized protein. (448 aa)
MAFMAF bZIP transcription factor; Belongs to the bZIP family. (404 aa)
ATG10Autophagy related 10. (234 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
ATG9BAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (929 aa)
UVRAGUV radiation resistance associated. (699 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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