(36 nodes) (2017) Characterization of developmental defects in the forebrain resulting from hyperactivated mTOR signaling by integrative analysis of transcriptomic and proteomic data. network (Capra hircus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	RHOA	Ras-like protein family member A. (193 aa)
	DRD2	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
	NRCAM	Neuronal cell adhesion molecule. (1304 aa)
	DUSP2	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (313 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	ARHGAP35	Rho GTPase activating protein 35. (1500 aa)
	EPHA8	EPH receptor A8. (1005 aa)
	NTRK1	Tyrosine-protein kinase receptor. (821 aa)
	ISL1	ISL LIM homeobox 1. (349 aa)
	PFN2	Profilin; Belongs to the profilin family. (140 aa)
	TLN2	Talin 2. (2542 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (397 aa)
	GSN	Gelsolin. (785 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	NTN1	Netrin 1. (496 aa)
	ADORA2A	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (384 aa)
	EGFR	Receptor protein-tyrosine kinase. (1208 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
	RASGRF1	Ras protein specific guanine nucleotide releasing factor 1. (1262 aa)
	BCL11B	BAF chromatin remodeling complex subunit BCL11B. (905 aa)
	PBX3	PBX homeobox 3. (434 aa)
	UCHL1	Ubiquitin C-terminal hydrolase L1. (248 aa)
	MYH10	Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1975 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
	ACTN1	Actinin alpha 1. (914 aa)
	ATF3	Activating transcription factor 3. (181 aa)
	ITGA5	Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1100 aa)
	SCIN	Scinderin. (715 aa)
	TSC2	Rap-GAP domain-containing protein. (1817 aa)
	ACTB	Uncharacterized protein. (375 aa)
	EMX1	Empty spiracles homeobox 1. (288 aa)
	DAB2	DAB adaptor protein 2. (768 aa)
	GPRIN1	G protein regulated inducer of neurite outgrowth 1. (923 aa)
	NGF	Nerve growth factor; Belongs to the NGF-beta family. (241 aa)
	FGF3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (232 aa)
	PPP1R12A	Protein phosphatase 1 regulatory subunit. (1029 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ACTN1	ENSCHIP00000011080	ENSCHIP00000015198	Uncharacterized protein.	Actinin alpha 1.	0.968
ACTB	AKT3	ENSCHIP00000011080	ENSCHIP00000030504	Uncharacterized protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.590
ACTB	ATF3	ENSCHIP00000011080	ENSCHIP00000014267	Uncharacterized protein.	Activating transcription factor 3.	0.608
ACTB	EGFR	ENSCHIP00000011080	ENSCHIP00000022759	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.891
ACTB	FGF3	ENSCHIP00000011080	ENSCHIP00000001019	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.514
ACTB	GSN	ENSCHIP00000011080	ENSCHIP00000023939	Uncharacterized protein.	Gelsolin.	0.579
ACTB	ISL1	ENSCHIP00000011080	ENSCHIP00000025978	Uncharacterized protein.	ISL LIM homeobox 1.	0.402
ACTB	ITGA5	ENSCHIP00000011080	ENSCHIP00000012972	Uncharacterized protein.	Integrin subunit alpha 5; Belongs to the integrin alpha chain family.	0.956
ACTB	MTOR	ENSCHIP00000011080	ENSCHIP00000021872	Uncharacterized protein.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.734
ACTB	MYH10	ENSCHIP00000011080	ENSCHIP00000019825	Uncharacterized protein.	Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.952
ACTB	NGF	ENSCHIP00000011080	ENSCHIP00000003583	Uncharacterized protein.	Nerve growth factor; Belongs to the NGF-beta family.	0.780
ACTB	NTN1	ENSCHIP00000011080	ENSCHIP00000023624	Uncharacterized protein.	Netrin 1.	0.474
ACTB	PFN2	ENSCHIP00000011080	ENSCHIP00000025145	Uncharacterized protein.	Profilin; Belongs to the profilin family.	0.984
ACTB	RHOA	ENSCHIP00000011080	ENSCHIP00000011951	Uncharacterized protein.	Ras-like protein family member A.	0.986
ACTB	SCIN	ENSCHIP00000011080	ENSCHIP00000012875	Uncharacterized protein.	Scinderin.	0.557
ACTB	TLN2	ENSCHIP00000011080	ENSCHIP00000024079	Uncharacterized protein.	Talin 2.	0.633
ACTB	TSC2	ENSCHIP00000011080	ENSCHIP00000012677	Uncharacterized protein.	Rap-GAP domain-containing protein.	0.679
ACTB	UCHL1	ENSCHIP00000011080	ENSCHIP00000020465	Uncharacterized protein.	Ubiquitin C-terminal hydrolase L1.	0.459
ACTN1	ACTB	ENSCHIP00000015198	ENSCHIP00000011080	Actinin alpha 1.	Uncharacterized protein.	0.968
ACTN1	EGFR	ENSCHIP00000015198	ENSCHIP00000022759	Actinin alpha 1.	Receptor protein-tyrosine kinase.	0.405