(26 nodes) (2017) Supplementation with small-extracellular vesicles from ovarian follicular fluid during in vitro production modulates bovine embryo development. network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC108633285	Uncharacterized protein. (200 aa)
	PDCD6IP	BRO1 domain-containing protein. (880 aa)
	PABPC1L	Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (648 aa)
	HDAC2	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
	PABPC1	Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (636 aa)
	DNMT1	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1591 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	CD63	Tetraspanin. (237 aa)
	IGF2	Insulin-like growth factor II. (179 aa)
	PABPC4	Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (660 aa)
	PABPC5	Poly(A) binding protein cytoplasmic 5. (382 aa)
	ALB	Serum albumin. (608 aa)
	CYC1	Cytochrome c1. (325 aa)
	GNRH1	Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. (92 aa)
	PXDN	Peroxidasin. (1525 aa)
	EED	Embryonic ectoderm development. (441 aa)
	DNMT3A	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (915 aa)
	ACTB	Uncharacterized protein. (375 aa)
	EHMT2	Euchromatic histone lysine methyltransferase 2. (1268 aa)
	EIF4B	RRM domain-containing protein. (615 aa)
	LOC102183049	Uncharacterized protein. (200 aa)
	EHMT1	Euchromatic histone lysine methyltransferase 1. (1293 aa)
	TET1	Tet methylcytosine dioxygenase 1. (2168 aa)
	EIF4E	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
	ACSL6	AMP-binding domain-containing protein. (722 aa)
	PABPC4L	Poly(A) binding protein cytoplasmic 4 like. (370 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ALB	ENSCHIP00000011080	ENSCHIP00000020234	Uncharacterized protein.	Serum albumin.	0.961
ACTB	CD63	ENSCHIP00000011080	ENSCHIP00000023741	Uncharacterized protein.	Tetraspanin.	0.795
ACTB	DNMT1	ENSCHIP00000011080	ENSCHIP00000027359	Uncharacterized protein.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.721
ACTB	DNMT3A	ENSCHIP00000011080	ENSCHIP00000012630	Uncharacterized protein.	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.729
ACTB	EIF4B	ENSCHIP00000011080	ENSCHIP00000009582	Uncharacterized protein.	RRM domain-containing protein.	0.429
ACTB	EIF4E	ENSCHIP00000011080	ENSCHIP00000005408	Uncharacterized protein.	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	0.712
ACTB	GAPDH	ENSCHIP00000011080	ENSCHIP00000025974	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.979
ACTB	GNRH1	ENSCHIP00000011080	ENSCHIP00000015958	Uncharacterized protein.	Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family.	0.430
ACTB	HDAC2	ENSCHIP00000011080	ENSCHIP00000028926	Uncharacterized protein.	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.719
ACTB	IGF2	ENSCHIP00000011080	ENSCHIP00000023369	Uncharacterized protein.	Insulin-like growth factor II.	0.661
ACTB	PXDN	ENSCHIP00000011080	ENSCHIP00000015493	Uncharacterized protein.	Peroxidasin.	0.962
ALB	ACTB	ENSCHIP00000020234	ENSCHIP00000011080	Serum albumin.	Uncharacterized protein.	0.961
ALB	CD63	ENSCHIP00000020234	ENSCHIP00000023741	Serum albumin.	Tetraspanin.	0.868
ALB	DNMT1	ENSCHIP00000020234	ENSCHIP00000027359	Serum albumin.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.506
ALB	DNMT3A	ENSCHIP00000020234	ENSCHIP00000012630	Serum albumin.	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.476
ALB	EIF4E	ENSCHIP00000020234	ENSCHIP00000005408	Serum albumin.	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	0.530
ALB	GAPDH	ENSCHIP00000020234	ENSCHIP00000025974	Serum albumin.	Glyceraldehyde-3-phosphate dehydrogenase.	0.948
ALB	GNRH1	ENSCHIP00000020234	ENSCHIP00000015958	Serum albumin.	Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family.	0.454
ALB	HDAC2	ENSCHIP00000020234	ENSCHIP00000028926	Serum albumin.	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.529
ALB	IGF2	ENSCHIP00000020234	ENSCHIP00000023369	Serum albumin.	Insulin-like growth factor II.	0.716