STRINGSTRING
CTNNB1 CTNNB1 CTSD CTSD LOC108636029 LOC108636029 LOC102181993 LOC102181993 TNF TNF LAMP3 LAMP3 IL6 IL6 STX4 STX4 STX6 STX6 SNAP23 SNAP23 STX3 STX3 ALB ALB LEP LEP HEXA HEXA HEXB HEXB CLDN1 CLDN1 AR AR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CTNNB1Catenin beta 1. (781 aa)
CTSDPeptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (412 aa)
LOC108636029Synaptosomal-associated protein; Belongs to the SNAP-25 family. (211 aa)
LOC102181993Beta-hexosaminidase. (556 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
LAMP3Uncharacterized protein. (433 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
STX4Syntaxin 4; Belongs to the syntaxin family. (296 aa)
STX6Syntaxin 6; Belongs to the syntaxin family. (238 aa)
SNAP23Synaptosomal-associated protein; Belongs to the SNAP-25 family. (208 aa)
STX3Syntaxin 3; Belongs to the syntaxin family. (289 aa)
ALBSerum albumin. (608 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa)
HEXABeta-hexosaminidase. (529 aa)
HEXBBeta-hexosaminidase. (540 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
ARAndrogen receptor. (891 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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