(6 nodes) (2017) eIF4B phosphorylation at Ser504 links synaptic activity with protein translation in physiology and pathology. network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PXDN	Peroxidasin. (1525 aa)
	RPS6	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (255 aa)
	EIF4E	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
	RPS6KB1	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (518 aa)
	CDK5	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
	EIF4B	RRM domain-containing protein. (615 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDK5	PXDN	ENSCHIP00000031665	ENSCHIP00000015493	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily.	Peroxidasin.	0.606
EIF4B	EIF4E	ENSCHIP00000009582	ENSCHIP00000005408	RRM domain-containing protein.	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	0.998
EIF4B	RPS6	ENSCHIP00000009582	ENSCHIP00000006669	RRM domain-containing protein.	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.	0.970
EIF4B	RPS6KB1	ENSCHIP00000009582	ENSCHIP00000002789	RRM domain-containing protein.	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	0.832
EIF4E	EIF4B	ENSCHIP00000005408	ENSCHIP00000009582	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	RRM domain-containing protein.	0.998
EIF4E	PXDN	ENSCHIP00000005408	ENSCHIP00000015493	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	Peroxidasin.	0.622
EIF4E	RPS6	ENSCHIP00000005408	ENSCHIP00000006669	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.	0.910
EIF4E	RPS6KB1	ENSCHIP00000005408	ENSCHIP00000002789	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	0.869
PXDN	CDK5	ENSCHIP00000015493	ENSCHIP00000031665	Peroxidasin.	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily.	0.606
PXDN	EIF4E	ENSCHIP00000015493	ENSCHIP00000005408	Peroxidasin.	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	0.622
PXDN	RPS6	ENSCHIP00000015493	ENSCHIP00000006669	Peroxidasin.	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.	0.597
PXDN	RPS6KB1	ENSCHIP00000015493	ENSCHIP00000002789	Peroxidasin.	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	0.616
RPS6	EIF4B	ENSCHIP00000006669	ENSCHIP00000009582	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.	RRM domain-containing protein.	0.970
RPS6	EIF4E	ENSCHIP00000006669	ENSCHIP00000005408	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	0.910
RPS6	PXDN	ENSCHIP00000006669	ENSCHIP00000015493	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.	Peroxidasin.	0.597
RPS6	RPS6KB1	ENSCHIP00000006669	ENSCHIP00000002789	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	0.930
RPS6KB1	EIF4B	ENSCHIP00000002789	ENSCHIP00000009582	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	RRM domain-containing protein.	0.832
RPS6KB1	EIF4E	ENSCHIP00000002789	ENSCHIP00000005408	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	0.869
RPS6KB1	PXDN	ENSCHIP00000002789	ENSCHIP00000015493	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	Peroxidasin.	0.616
RPS6KB1	RPS6	ENSCHIP00000002789	ENSCHIP00000006669	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.	0.930