node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BECN1 | LEP | ENSCHIP00000024304 | ENSCHIP00000021235 | Uncharacterized protein. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | 0.473 |
CACNB1 | MPRIP | ENSCHIP00000024896 | ENSCHIP00000016249 | Calcium voltage-gated channel auxiliary subunit beta 1. | Uncharacterized protein. | 0.544 |
CACNB1 | UTS2R | ENSCHIP00000024896 | ENSCHIP00000009228 | Calcium voltage-gated channel auxiliary subunit beta 1. | Urotensin 2 receptor. | 0.703 |
FASN | LEP | ENSCHIP00000019407 | ENSCHIP00000021235 | Fatty acid synthase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | 0.669 |
LEP | BECN1 | ENSCHIP00000021235 | ENSCHIP00000024304 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | Uncharacterized protein. | 0.473 |
LEP | FASN | ENSCHIP00000021235 | ENSCHIP00000019407 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | Fatty acid synthase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. | 0.669 |
LEP | MSTN | ENSCHIP00000021235 | ENSCHIP00000026815 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | Growth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth; Belongs to the TGF-beta family. | 0.612 |
MPRIP | CACNB1 | ENSCHIP00000016249 | ENSCHIP00000024896 | Uncharacterized protein. | Calcium voltage-gated channel auxiliary subunit beta 1. | 0.544 |
MPRIP | MYH13 | ENSCHIP00000016249 | ENSCHIP00000008782 | Uncharacterized protein. | Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.594 |
MPRIP | NT5M | ENSCHIP00000016249 | ENSCHIP00000018743 | Uncharacterized protein. | 5',3'-nucleotidase, mitochondrial. | 0.772 |
MPRIP | SECTM1 | ENSCHIP00000016249 | ENSCHIP00000022379 | Uncharacterized protein. | Uncharacterized protein. | 0.516 |
MPRIP | TCAP | ENSCHIP00000016249 | ENSCHIP00000001814 | Uncharacterized protein. | Uncharacterized protein. | 0.456 |
MPRIP | UTS2R | ENSCHIP00000016249 | ENSCHIP00000009228 | Uncharacterized protein. | Urotensin 2 receptor. | 0.796 |
MSTN | LEP | ENSCHIP00000026815 | ENSCHIP00000021235 | Growth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth; Belongs to the TGF-beta family. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | 0.612 |
MSTN | MYH2 | ENSCHIP00000026815 | ENSCHIP00000032970 | Growth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth; Belongs to the TGF-beta family. | Myosin heavy chain 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.557 |
MSTN | MYH3 | ENSCHIP00000026815 | ENSCHIP00000022678 | Growth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth; Belongs to the TGF-beta family. | Myosin heavy chain 3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.535 |
MYH13 | MPRIP | ENSCHIP00000008782 | ENSCHIP00000016249 | Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Uncharacterized protein. | 0.594 |
MYH13 | TCAP | ENSCHIP00000008782 | ENSCHIP00000001814 | Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Uncharacterized protein. | 0.436 |
MYH13 | UTS2R | ENSCHIP00000008782 | ENSCHIP00000009228 | Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Urotensin 2 receptor. | 0.607 |
MYH2 | MSTN | ENSCHIP00000032970 | ENSCHIP00000026815 | Myosin heavy chain 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Growth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth; Belongs to the TGF-beta family. | 0.557 |