8 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa)
	GOT1	Aspartate aminotransferase. (413 aa)
	POLE2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (518 aa)
	RPA3	Uncharacterized protein. (121 aa)
	ALB	Serum albumin. (608 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (275 aa)
	GOT2	Aspartate aminotransferase. (430 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALB	CASP3	ENSCHIP00000020234	ENSCHIP00000011490	Serum albumin.	Caspase 3; Belongs to the peptidase C14A family.	0.892
ALB	GOT1	ENSCHIP00000020234	ENSCHIP00000029101	Serum albumin.	Aspartate aminotransferase.	0.972
ALB	GOT2	ENSCHIP00000020234	ENSCHIP00000010968	Serum albumin.	Aspartate aminotransferase.	0.954
CASP3	ALB	ENSCHIP00000011490	ENSCHIP00000020234	Caspase 3; Belongs to the peptidase C14A family.	Serum albumin.	0.892
CASP3	GOT1	ENSCHIP00000011490	ENSCHIP00000029101	Caspase 3; Belongs to the peptidase C14A family.	Aspartate aminotransferase.	0.766
CASP3	GOT2	ENSCHIP00000011490	ENSCHIP00000010968	Caspase 3; Belongs to the peptidase C14A family.	Aspartate aminotransferase.	0.757
GOT1	ALB	ENSCHIP00000029101	ENSCHIP00000020234	Aspartate aminotransferase.	Serum albumin.	0.972
GOT1	CASP3	ENSCHIP00000029101	ENSCHIP00000011490	Aspartate aminotransferase.	Caspase 3; Belongs to the peptidase C14A family.	0.766
GOT1	GOT2	ENSCHIP00000029101	ENSCHIP00000010968	Aspartate aminotransferase.	Aspartate aminotransferase.	0.983
GOT2	ALB	ENSCHIP00000010968	ENSCHIP00000020234	Aspartate aminotransferase.	Serum albumin.	0.954
GOT2	CASP3	ENSCHIP00000010968	ENSCHIP00000011490	Aspartate aminotransferase.	Caspase 3; Belongs to the peptidase C14A family.	0.757
GOT2	GOT1	ENSCHIP00000010968	ENSCHIP00000029101	Aspartate aminotransferase.	Aspartate aminotransferase.	0.983
PCNA	POLE2	ENSCHIP00000015091	ENSCHIP00000028310	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.778
PCNA	RPA1	ENSCHIP00000015091	ENSCHIP00000032279	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.939
PCNA	RPA3	ENSCHIP00000015091	ENSCHIP00000027638	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Uncharacterized protein.	0.622
POLE2	PCNA	ENSCHIP00000028310	ENSCHIP00000015091	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.778
POLE2	RPA1	ENSCHIP00000028310	ENSCHIP00000032279	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.862
POLE2	RPA3	ENSCHIP00000028310	ENSCHIP00000027638	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	Uncharacterized protein.	0.771
RPA1	PCNA	ENSCHIP00000032279	ENSCHIP00000015091	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.939
RPA1	POLE2	ENSCHIP00000032279	ENSCHIP00000028310	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.862