(15 nodes) (2017) Porphyromonas gingivalis lipopolysaccharide stimulation in human periodontal ligament stem cells: role of epigenetic modifications to the inflammation. network (Capra hircus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	DNMT3B	DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (872 aa)
	MMP1	Matrix metallopeptidase 1. (475 aa)
	MMP16	Matrix metallopeptidase 16. (607 aa)
	ACTB	Uncharacterized protein. (375 aa)
	IFNGR1	Interferon gamma receptor 1. (500 aa)
	DNMT3A	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (915 aa)
	TNFAIP1	TNF alpha induced protein 1. (316 aa)
	PXDN	Peroxidasin. (1525 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
	TLR4	TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (464 aa)
	DNMT1	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1591 aa)
	HDAC2	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
	APP	Amyloid beta precursor protein. (770 aa)
	APPBP2	Amyloid beta precursor protein binding protein 2. (585 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	APP	ENSCHIP00000011080	ENSCHIP00000032622	Uncharacterized protein.	Amyloid beta precursor protein.	0.778
ACTB	DNMT1	ENSCHIP00000011080	ENSCHIP00000027359	Uncharacterized protein.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.721
ACTB	DNMT3A	ENSCHIP00000011080	ENSCHIP00000012630	Uncharacterized protein.	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.729
ACTB	DNMT3B	ENSCHIP00000011080	ENSCHIP00000002727	Uncharacterized protein.	DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.529
ACTB	HDAC1	ENSCHIP00000011080	ENSCHIP00000022688	Uncharacterized protein.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.791
ACTB	HDAC2	ENSCHIP00000011080	ENSCHIP00000028926	Uncharacterized protein.	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.719
ACTB	MMP1	ENSCHIP00000011080	ENSCHIP00000006699	Uncharacterized protein.	Matrix metallopeptidase 1.	0.484
ACTB	MYD88	ENSCHIP00000011080	ENSCHIP00000018063	Uncharacterized protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.826
ACTB	PXDN	ENSCHIP00000011080	ENSCHIP00000015493	Uncharacterized protein.	Peroxidasin.	0.962
ACTB	TLR4	ENSCHIP00000011080	ENSCHIP00000019512	Uncharacterized protein.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.879
APP	ACTB	ENSCHIP00000032622	ENSCHIP00000011080	Amyloid beta precursor protein.	Uncharacterized protein.	0.778
APP	APPBP2	ENSCHIP00000032622	ENSCHIP00000033650	Amyloid beta precursor protein.	Amyloid beta precursor protein binding protein 2.	0.649
APP	PXDN	ENSCHIP00000032622	ENSCHIP00000015493	Amyloid beta precursor protein.	Peroxidasin.	0.622
APP	TLR4	ENSCHIP00000032622	ENSCHIP00000019512	Amyloid beta precursor protein.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.557
APPBP2	APP	ENSCHIP00000033650	ENSCHIP00000032622	Amyloid beta precursor protein binding protein 2.	Amyloid beta precursor protein.	0.649
DNMT1	ACTB	ENSCHIP00000027359	ENSCHIP00000011080	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Uncharacterized protein.	0.721
DNMT1	DNMT3A	ENSCHIP00000027359	ENSCHIP00000012630	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.982
DNMT1	DNMT3B	ENSCHIP00000027359	ENSCHIP00000002727	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.994
DNMT1	HDAC1	ENSCHIP00000027359	ENSCHIP00000022688	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.990
DNMT1	HDAC2	ENSCHIP00000027359	ENSCHIP00000028926	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.933