STRINGSTRING
HOXC8 HOXC8 ETAA1 ETAA1 ALDH3A2 ALDH3A2 CLDN6 CLDN6 CYP2E1 CYP2E1 JUN JUN HOXA9 HOXA9 KLF7 KLF7 PDGFD PDGFD HOXC10 HOXC10 ENSCHIP00000003120 ENSCHIP00000003120 HOXC12 HOXC12 TNF TNF NOG NOG OSMR OSMR NR4A1 NR4A1 BMP7 BMP7 BMP5 BMP5 PITX2 PITX2 THBD THBD WNT2 WNT2 INS INS DKK3 DKK3 IL6 IL6 COL11A2 COL11A2 SP9 SP9 PNPLA3 PNPLA3 HOXC6 HOXC6 VSIG4 VSIG4 ACTB ACTB TBX15 TBX15 HOXA10 HOXA10 PPP1CC PPP1CC PROKR1 PROKR1 BAMBI BAMBI CPT1A CPT1A HOXA6 HOXA6 TCF21 TCF21 PPARG PPARG HOXC9 HOXC9 ICAM1 ICAM1 PPARGC1A PPARGC1A ALDH3B2 ALDH3B2 ENSCHIP00000017274 ENSCHIP00000017274 FZD6 FZD6 HOXB7 HOXB7 IRX1 IRX1 ALDH1A1 ALDH1A1 SCD5 SCD5 DLK1 DLK1 FASN FASN HOXA11 HOXA11 ALDH1A3 ALDH1A3 SCD SCD COL1A1 COL1A1 FRZB FRZB AR AR TNXB TNXB WDR92 WDR92 BCO1 BCO1 SFRP2 SFRP2 HOXB5 HOXB5 CLCN5 CLCN5 LOC102183297 LOC102183297 SP3 SP3 SLC27A6 SLC27A6 PDGFRB PDGFRB GATA3 GATA3 HOXC11 HOXC11 HOXC13 HOXC13 ALDH3A1 ALDH3A1 HOXB2 HOXB2 HOXC4 HOXC4 ALDH3B1 ALDH3B1 ADIPOQ ADIPOQ CLDN15 CLDN15
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HOXC8Homeobox C8. (242 aa)
ETAA1ETAA1 activator of ATR kinase. (903 aa)
ALDH3A2Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (500 aa)
CLDN6Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (221 aa)
CYP2E1Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family. (495 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
HOXA9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (279 aa)
KLF7Kruppel-like factor 7. (302 aa)
PDGFDPlatelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (370 aa)
HOXC10Homeobox C10. (342 aa)
ENSCHIP00000003120Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (462 aa)
HOXC12Homeobox C12. (278 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
OSMROncostatin M receptor. (948 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (623 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
PITX2Homeobox protein. (325 aa)
THBDThrombomodulin. (578 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
DKK3Dickkopf WNT signaling pathway inhibitor 3. (349 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
COL11A2Collagen type XI alpha 2 chain. (1583 aa)
SP9Sp9 transcription factor. (481 aa)
PNPLA3Patatin like phospholipase domain containing 3. (447 aa)
HOXC6Homeobox C6. (235 aa)
VSIG4V-set and immunoglobulin domain containing 4. (352 aa)
ACTBUncharacterized protein. (375 aa)
TBX15T-box transcription factor 15. (602 aa)
HOXA10Homeobox A10. (413 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (314 aa)
PROKR1Prokineticin receptor 1; Belongs to the G-protein coupled receptor 1 family. (393 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
CPT1ACarnitine O-palmitoyltransferase 1; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
HOXA6Homeobox A6. (233 aa)
TCF21Transcription factor 21. (179 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
HOXC9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (260 aa)
ICAM1Intercellular adhesion molecule 1. (532 aa)
PPARGC1ARRM domain-containing protein. (797 aa)
ALDH3B2Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (466 aa)
ENSCHIP00000017274Uncharacterized protein. (535 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (714 aa)
HOXB7Homeobox B7. (217 aa)
IRX1Iroquois homeobox 1. (475 aa)
ALDH1A1Aldehyde dehydrogenase 1 family member A1; Belongs to the aldehyde dehydrogenase family. (501 aa)
SCD5Stearoyl-CoA desaturase 5; Belongs to the fatty acid desaturase type 1 family. (337 aa)
DLK1Uncharacterized protein. (380 aa)
FASNFatty acid synthase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. (2755 aa)
HOXA11Homeobox A11. (317 aa)
ALDH1A3Aldehyde dehydrogenase 1 family member A3; Belongs to the aldehyde dehydrogenase family. (512 aa)
SCDAcyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (By similarity). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid ox [...] (359 aa)
COL1A1Collagen type I alpha 1 chain. (1463 aa)
FRZBFrizzled related protein. (325 aa)
ARAndrogen receptor. (891 aa)
TNXBUncharacterized protein. (1470 aa)
WDR92WD repeat domain 92. (357 aa)
BCO1Beta-carotene oxygenase 1. (579 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
HOXB5Homeobox B5. (269 aa)
CLCN5Chloride channel protein. (816 aa)
LOC102183297Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (317 aa)
SP3Sp3 transcription factor. (778 aa)
SLC27A6Solute carrier family 27 member 6. (634 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
GATA3GATA binding protein 3. (467 aa)
HOXC11Homeobox C11. (304 aa)
HOXC13Homeobox C13. (330 aa)
ALDH3A1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (453 aa)
HOXB2Homeobox B2. (354 aa)
HOXC4Homeobox C4. (264 aa)
ALDH3B1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (468 aa)
ADIPOQC1q domain-containing protein. (283 aa)
CLDN15Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (235 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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