25 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IGFBP2	Uncharacterized protein. (326 aa)
	NFE2L2	Nuclear factor erythroid 2-related factor 2. (616 aa)
	POU1F1	Uncharacterized protein. (261 aa)
	LOC102168954	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (219 aa)
	PRDX1	Thioredoxin domain-containing protein. (206 aa)
	SOD2	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
	ATP5F1B	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (528 aa)
	KEAP1	Kelch like ECH associated protein 1. (624 aa)
	ACTB	Uncharacterized protein. (375 aa)
	PXDN	Peroxidasin. (1525 aa)
	ATP5MC1	ATP-synt_C domain-containing protein; Belongs to the ATPase C chain family. (136 aa)
	ATP5MC3	ATP-synt_C domain-containing protein; Belongs to the ATPase C chain family. (141 aa)
	ATP5F1C	ATP synthase subunit gamma. (298 aa)
	PRDX3	Peroxiredoxin 3. (257 aa)
	IGF1	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (188 aa)
	ALB	Serum albumin. (608 aa)
	GPX6	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (223 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa)
	ENSCHIP00000023849	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (177 aa)
	NOX4	NADPH oxidase 4. (578 aa)
	PRDX4	Peroxiredoxin 4. (275 aa)
	GPX8	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (209 aa)
	DMAC2L	Distal membrane arm assembly complex 2 like. (200 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1367 aa)
	GPX7	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (186 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ALB	ENSCHIP00000011080	ENSCHIP00000020234	Uncharacterized protein.	Serum albumin.	0.961
ACTB	ATP5F1B	ENSCHIP00000011080	ENSCHIP00000007152	Uncharacterized protein.	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.633
ACTB	ENSCHIP00000023849	ENSCHIP00000011080	ENSCHIP00000023849	Uncharacterized protein.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.718
ACTB	GPX6	ENSCHIP00000011080	ENSCHIP00000020908	Uncharacterized protein.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.704
ACTB	GPX7	ENSCHIP00000011080	ENSCHIP00000029981	Uncharacterized protein.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.717
ACTB	GPX8	ENSCHIP00000011080	ENSCHIP00000026386	Uncharacterized protein.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.717
ACTB	IGF1	ENSCHIP00000011080	ENSCHIP00000020185	Uncharacterized protein.	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	0.790
ACTB	IGF1R	ENSCHIP00000011080	ENSCHIP00000028488	Uncharacterized protein.	Tyrosine-protein kinase receptor.	0.754
ACTB	KEAP1	ENSCHIP00000011080	ENSCHIP00000009131	Uncharacterized protein.	Kelch like ECH associated protein 1.	0.780
ACTB	LEP	ENSCHIP00000011080	ENSCHIP00000021235	Uncharacterized protein.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]	0.846
ACTB	LOC102168954	ENSCHIP00000011080	ENSCHIP00000004343	Uncharacterized protein.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.716
ACTB	NFE2L2	ENSCHIP00000011080	ENSCHIP00000031851	Uncharacterized protein.	Nuclear factor erythroid 2-related factor 2.	0.716
ACTB	NOX4	ENSCHIP00000011080	ENSCHIP00000024501	Uncharacterized protein.	NADPH oxidase 4.	0.778
ACTB	PRDX1	ENSCHIP00000011080	ENSCHIP00000005982	Uncharacterized protein.	Thioredoxin domain-containing protein.	0.635
ACTB	PRDX3	ENSCHIP00000011080	ENSCHIP00000019739	Uncharacterized protein.	Peroxiredoxin 3.	0.452
ACTB	PXDN	ENSCHIP00000011080	ENSCHIP00000015493	Uncharacterized protein.	Peroxidasin.	0.962
ACTB	SOD2	ENSCHIP00000011080	ENSCHIP00000006131	Uncharacterized protein.	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.	0.770
ALB	ACTB	ENSCHIP00000020234	ENSCHIP00000011080	Serum albumin.	Uncharacterized protein.	0.961
ALB	ENSCHIP00000023849	ENSCHIP00000020234	ENSCHIP00000023849	Serum albumin.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.701
ALB	GPX6	ENSCHIP00000020234	ENSCHIP00000020908	Serum albumin.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.820