(23 nodes) (2018) Systematic analysis of ATG13 domain requirements for autophagy induction. network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	GJA1	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
	VAMP7	Vesicle associated membrane protein 7; Belongs to the synaptobrevin family. (220 aa)
	VCL	Vinculin. (1134 aa)
	FKBP1A	Peptidylprolyl isomerase. (108 aa)
	SIRT1	Deacetylase sirtuin-type domain-containing protein. (732 aa)
	ULK2	Unc-51 like autophagy activating kinase 2. (1035 aa)
	ACTB	Uncharacterized protein. (375 aa)
	MAP1B	Microtubule associated protein 1B. (2468 aa)
	ATG14	Autophagy related 14. (492 aa)
	PXDN	Peroxidasin. (1525 aa)
	MAP1A	Microtubule associated protein 1A. (3098 aa)
	ATG101	Autophagy related 101. (218 aa)
	BLNK	B cell linker. (384 aa)
	RB1CC1	RB1 inducible coiled-coil 1. (1589 aa)
	ULK1	Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (1055 aa)
	MAP1S	Microtubule associated protein 1S. (1066 aa)
	RPTOR	Regulatory associated protein of MTOR complex 1. (1342 aa)
	GABARAP	GABA type A receptor-associated protein. (117 aa)
	SQSTM1	Sequestosome 1. (440 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (495 aa)
	WIPI2	WD repeat domain, phosphoinositide interacting 2. (436 aa)
	TG	Thyroglobulin. (2757 aa)
	ATG16L1	Autophagy related 16 like 1. (607 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	AKT1	ENSCHIP00000011080	ENSCHIP00000027335	Uncharacterized protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.755
ACTB	ATG14	ENSCHIP00000011080	ENSCHIP00000014942	Uncharacterized protein.	Autophagy related 14.	0.404
ACTB	ATG16L1	ENSCHIP00000011080	ENSCHIP00000032565	Uncharacterized protein.	Autophagy related 16 like 1.	0.574
ACTB	GABARAP	ENSCHIP00000011080	ENSCHIP00000024185	Uncharacterized protein.	GABA type A receptor-associated protein.	0.451
ACTB	GJA1	ENSCHIP00000011080	ENSCHIP00000001879	Uncharacterized protein.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.665
ACTB	MAP1A	ENSCHIP00000011080	ENSCHIP00000016076	Uncharacterized protein.	Microtubule associated protein 1A.	0.732
ACTB	MAP1B	ENSCHIP00000011080	ENSCHIP00000011673	Uncharacterized protein.	Microtubule associated protein 1B.	0.707
ACTB	MAP1S	ENSCHIP00000011080	ENSCHIP00000021533	Uncharacterized protein.	Microtubule associated protein 1S.	0.705
ACTB	PXDN	ENSCHIP00000011080	ENSCHIP00000015493	Uncharacterized protein.	Peroxidasin.	0.962
ACTB	SIRT1	ENSCHIP00000011080	ENSCHIP00000007571	Uncharacterized protein.	Deacetylase sirtuin-type domain-containing protein.	0.852
ACTB	SQSTM1	ENSCHIP00000011080	ENSCHIP00000026704	Uncharacterized protein.	Sequestosome 1.	0.774
ACTB	VCL	ENSCHIP00000011080	ENSCHIP00000000453	Uncharacterized protein.	Vinculin.	0.988
AKT1	ACTB	ENSCHIP00000027335	ENSCHIP00000011080	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.755
AKT1	PXDN	ENSCHIP00000027335	ENSCHIP00000015493	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Peroxidasin.	0.637
AKT1	RPTOR	ENSCHIP00000027335	ENSCHIP00000023237	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Regulatory associated protein of MTOR complex 1.	0.965
AKT1	SIRT1	ENSCHIP00000027335	ENSCHIP00000007571	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Deacetylase sirtuin-type domain-containing protein.	0.641
AKT1	SQSTM1	ENSCHIP00000027335	ENSCHIP00000026704	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Sequestosome 1.	0.430
ATG101	ATG14	ENSCHIP00000017295	ENSCHIP00000014942	Autophagy related 101.	Autophagy related 14.	0.996
ATG101	ATG16L1	ENSCHIP00000017295	ENSCHIP00000032565	Autophagy related 101.	Autophagy related 16 like 1.	0.873
ATG101	GABARAP	ENSCHIP00000017295	ENSCHIP00000024185	Autophagy related 101.	GABA type A receptor-associated protein.	0.718