27 items (Capra hircus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
	CCL2	C-C motif chemokine. (98 aa)
	COL14A1	Collagen type XIV alpha 1 chain. (1775 aa)
	COL5A2	Collagen type V alpha 2 chain. (1252 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	PXDN	Peroxidasin. (1525 aa)
	CCL5	C-C motif chemokine. (91 aa)
	IL10	Interleukin 10. (177 aa)
	CXCL11	C-X-C motif chemokine. (87 aa)
	FGA	Fibrinogen alpha chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it [...] (618 aa)
	IGF1	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (188 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (135 aa)
	CCR2	C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (339 aa)
	COL1A1	Collagen type I alpha 1 chain. (1463 aa)
	CXCL9	C-X-C motif chemokine. (125 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	HBEGF	Heparin binding EGF like growth factor. (208 aa)
	LOC102179993	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (355 aa)
	FGA-2	Fibrinogen C-terminal domain-containing protein. (206 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (402 aa)
	CCR8	C-C motif chemokine receptor 8; Belongs to the G-protein coupled receptor 1 family. (366 aa)
	PLG	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (816 aa)
	CX3CL1	SCY domain-containing protein. (430 aa)
	COL1A2	Collagen type I alpha 2 chain. (1128 aa)
	CCR6	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (375 aa)
	CCN2	Cellular communication network factor 2. (349 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCL2	CCL5	ENSCHIP00000027804	ENSCHIP00000016425	C-C motif chemokine.	C-C motif chemokine.	0.983
CCL2	CCN2	ENSCHIP00000027804	ENSCHIP00000030116	C-C motif chemokine.	Cellular communication network factor 2.	0.574
CCL2	CCR2	ENSCHIP00000027804	ENSCHIP00000022774	C-C motif chemokine.	C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.999
CCL2	CCR6	ENSCHIP00000027804	ENSCHIP00000030832	C-C motif chemokine.	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	0.921
CCL2	CCR8	ENSCHIP00000027804	ENSCHIP00000002985	C-C motif chemokine.	C-C motif chemokine receptor 8; Belongs to the G-protein coupled receptor 1 family.	0.953
CCL2	COL1A1	ENSCHIP00000027804	ENSCHIP00000023918	C-C motif chemokine.	Collagen type I alpha 1 chain.	0.586
CCL2	CX3CL1	ENSCHIP00000027804	ENSCHIP00000028797	C-C motif chemokine.	SCY domain-containing protein.	0.590
CCL2	CXCL11	ENSCHIP00000027804	ENSCHIP00000017661	C-C motif chemokine.	C-X-C motif chemokine.	0.860
CCL2	CXCL9	ENSCHIP00000027804	ENSCHIP00000024309	C-C motif chemokine.	C-X-C motif chemokine.	0.991
CCL2	GAPDH	ENSCHIP00000027804	ENSCHIP00000025974	C-C motif chemokine.	Glyceraldehyde-3-phosphate dehydrogenase.	0.809
CCL2	IGF1	ENSCHIP00000027804	ENSCHIP00000020185	C-C motif chemokine.	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	0.612
CCL2	IL10	ENSCHIP00000027804	ENSCHIP00000016929	C-C motif chemokine.	Interleukin 10.	0.930
CCL2	IL1B	ENSCHIP00000027804	ENSCHIP00000029274	C-C motif chemokine.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.933
CCL2	IL4	ENSCHIP00000027804	ENSCHIP00000020527	C-C motif chemokine.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	0.825
CCL2	IL6	ENSCHIP00000027804	ENSCHIP00000009414	C-C motif chemokine.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.962
CCL2	LOC102179993	ENSCHIP00000027804	ENSCHIP00000001467	C-C motif chemokine.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.986
CCL2	PXDN	ENSCHIP00000027804	ENSCHIP00000015493	C-C motif chemokine.	Peroxidasin.	0.693
CCL5	CCL2	ENSCHIP00000016425	ENSCHIP00000027804	C-C motif chemokine.	C-C motif chemokine.	0.983
CCL5	CCR2	ENSCHIP00000016425	ENSCHIP00000022774	C-C motif chemokine.	C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.998
CCL5	CCR6	ENSCHIP00000016425	ENSCHIP00000030832	C-C motif chemokine.	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.	0.947