(14 nodes) (2017) Loss of NEIL3 DNA glycosylase markedly increases replication associated double strand breaks and enhances sensitivity to ATR inhibitor in glioblastoma cells. network (Capra hircus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

gene neighborhood

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textmining

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protein homology

Your Input:
	CCP110	Centriolar coiled-coil protein 110. (1006 aa)
	DNMT1	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1591 aa)
	MSH6	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1361 aa)
	SMARCA5	Uncharacterized protein. (1052 aa)
	NCK1	Cytoplasmic protein. (377 aa)
	NCK2	Cytoplasmic protein. (376 aa)
	SMARCA1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1. (1114 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
	NEIL3	Nei like DNA glycosylase 3. (606 aa)
	GP2	ZP domain-containing protein. (543 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	BAZ1B	Bromodomain adjacent to zinc finger domain 1B. (1482 aa)
	XRCC1	X-ray repair cross complementing 1. (632 aa)
	OGG1	8-oxoguanine DNA glycosylase. (345 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAZ1B	CCP110	ENSCHIP00000020502	ENSCHIP00000024454	Bromodomain adjacent to zinc finger domain 1B.	Centriolar coiled-coil protein 110.	0.813
BAZ1B	DNMT1	ENSCHIP00000020502	ENSCHIP00000027359	Bromodomain adjacent to zinc finger domain 1B.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.444
BAZ1B	MSH6	ENSCHIP00000020502	ENSCHIP00000012330	Bromodomain adjacent to zinc finger domain 1B.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.653
BAZ1B	NEIL3	ENSCHIP00000020502	ENSCHIP00000005007	Bromodomain adjacent to zinc finger domain 1B.	Nei like DNA glycosylase 3.	0.487
BAZ1B	SMARCA1	ENSCHIP00000020502	ENSCHIP00000005821	Bromodomain adjacent to zinc finger domain 1B.	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1.	0.882
BAZ1B	SMARCA5	ENSCHIP00000020502	ENSCHIP00000011693	Bromodomain adjacent to zinc finger domain 1B.	Uncharacterized protein.	0.986
CCP110	BAZ1B	ENSCHIP00000024454	ENSCHIP00000020502	Centriolar coiled-coil protein 110.	Bromodomain adjacent to zinc finger domain 1B.	0.813
CCP110	DNMT1	ENSCHIP00000024454	ENSCHIP00000027359	Centriolar coiled-coil protein 110.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.635
CCP110	MSH6	ENSCHIP00000024454	ENSCHIP00000012330	Centriolar coiled-coil protein 110.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.711
CCP110	NEIL3	ENSCHIP00000024454	ENSCHIP00000005007	Centriolar coiled-coil protein 110.	Nei like DNA glycosylase 3.	0.697
CCP110	SMARCA1	ENSCHIP00000024454	ENSCHIP00000005821	Centriolar coiled-coil protein 110.	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1.	0.811
CCP110	SMARCA5	ENSCHIP00000024454	ENSCHIP00000011693	Centriolar coiled-coil protein 110.	Uncharacterized protein.	0.758
CCP110	XRCC1	ENSCHIP00000024454	ENSCHIP00000022965	Centriolar coiled-coil protein 110.	X-ray repair cross complementing 1.	0.527
DNMT1	BAZ1B	ENSCHIP00000027359	ENSCHIP00000020502	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Bromodomain adjacent to zinc finger domain 1B.	0.444
DNMT1	CCP110	ENSCHIP00000027359	ENSCHIP00000024454	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Centriolar coiled-coil protein 110.	0.635
DNMT1	FEN1	ENSCHIP00000027359	ENSCHIP00000005017	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.440
DNMT1	MSH6	ENSCHIP00000027359	ENSCHIP00000012330	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.665
DNMT1	PCNA	ENSCHIP00000027359	ENSCHIP00000015091	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.916
FEN1	DNMT1	ENSCHIP00000005017	ENSCHIP00000027359	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.440
FEN1	MSH6	ENSCHIP00000005017	ENSCHIP00000012330	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.899