(70 nodes) (2018) Dynamic transcriptome profiling towards understanding the morphogenesis and development of diverse feather in domestic duck. network (Capra hircus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	FZD5	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
	HOXC9	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (260 aa)
	HOXB8	Homeobox B8. (243 aa)
	FGF12	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
	BAMBI	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
	DVL1	Dishevelled segment polarity protein 1. (682 aa)
	DKK1	Dickkopf WNT signaling pathway inhibitor 1. (262 aa)
	WNT5B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
	HOXB3	Homeobox B3. (426 aa)
	PTCH1	Patched 1. (1453 aa)
	ACTB	Uncharacterized protein. (375 aa)
	FZD1	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (552 aa)
	WIF1	WNT inhibitory factor 1. (379 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	HOXD10	Homeobox D10. (340 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	EDARADD	EDAR associated death domain. (205 aa)
	FGFR1	Fibroblast growth factor receptor. (860 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	TCF7L1	Transcription factor 7 like 1. (587 aa)
	CCND1	Cyclin D1; Belongs to the cyclin family. (295 aa)
	PITX2	Homeobox protein. (325 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	HOXB6	Homeobox B6. (224 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
	FGFR3	Receptor protein-tyrosine kinase. (710 aa)
	HOXC10	Homeobox C10. (342 aa)
	HHIP	Hedgehog interacting protein. (701 aa)
	GJA1	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
	FGF14	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (247 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	HOXC8	Homeobox C8. (242 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	FZD8	Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (665 aa)
	FZD7	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (579 aa)
	FMOD	Fibromodulin. (376 aa)
	FZD4	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (555 aa)
	HOXD11	Homeobox D11. (337 aa)
	DKK2	Dickkopf WNT signaling pathway inhibitor 2. (259 aa)
	HOXB2	Homeobox B2. (354 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	HOXB4	Homeobox B4. (251 aa)
	LEF1	HMG box domain-containing protein. (430 aa)
	HOXC13	Homeobox C13. (330 aa)
	EDAR	Ectodysplasin A receptor. (441 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
	FZD3	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
	WNT6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
	EFNA3	Ephrin RBD domain-containing protein; Belongs to the ephrin family. (232 aa)
	HOXB5	Homeobox B5. (269 aa)
	WNT10A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (416 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	FRZB	Frizzled related protein. (325 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	TBX4	T-box transcription factor 4. (556 aa)
	AXIN2	Axin 2. (844 aa)
	SMAD7	Mothers against decapentaplegic homolog. (427 aa)
	SMAD4	Mothers against decapentaplegic homolog. (513 aa)
	CRABP1	Cellular retinoic acid binding protein 1; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (137 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	MGP	Matrix Gla protein; Associates with the organic matrix of bone and cartilage. (101 aa)
	PTCH2	Patched 2. (1207 aa)
	WNT16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
	PDGFC	Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (397 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	AXIN2	ENSCHIP00000011080	ENSCHIP00000022676	Uncharacterized protein.	Axin 2.	0.666
ACTB	BMP4	ENSCHIP00000011080	ENSCHIP00000023678	Uncharacterized protein.	Bone morphogenetic protein 4.	0.697
ACTB	BMPR1A	ENSCHIP00000011080	ENSCHIP00000000640	Uncharacterized protein.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.402
ACTB	CCND1	ENSCHIP00000011080	ENSCHIP00000006815	Uncharacterized protein.	Cyclin D1; Belongs to the cyclin family.	0.890
ACTB	CTNNB1	ENSCHIP00000011080	ENSCHIP00000031016	Uncharacterized protein.	Catenin beta 1.	0.906
ACTB	DKK1	ENSCHIP00000011080	ENSCHIP00000013400	Uncharacterized protein.	Dickkopf WNT signaling pathway inhibitor 1.	0.625
ACTB	FGF1	ENSCHIP00000011080	ENSCHIP00000033180	Uncharacterized protein.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.469
ACTB	FGF12	ENSCHIP00000011080	ENSCHIP00000014304	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.457
ACTB	FGF18	ENSCHIP00000011080	ENSCHIP00000008198	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.534
ACTB	FGF2	ENSCHIP00000011080	ENSCHIP00000019134	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.763
ACTB	FGF9	ENSCHIP00000011080	ENSCHIP00000022948	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.563
ACTB	FGFR1	ENSCHIP00000011080	ENSCHIP00000007607	Uncharacterized protein.	Fibroblast growth factor receptor.	0.691
ACTB	FGFR3	ENSCHIP00000011080	ENSCHIP00000003263	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.530
ACTB	GJA1	ENSCHIP00000011080	ENSCHIP00000001879	Uncharacterized protein.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.665
ACTB	LEF1	ENSCHIP00000011080	ENSCHIP00000030629	Uncharacterized protein.	HMG box domain-containing protein.	0.657
ACTB	NOG	ENSCHIP00000011080	ENSCHIP00000005264	Uncharacterized protein.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.580
ACTB	PTCH1	ENSCHIP00000011080	ENSCHIP00000011891	Uncharacterized protein.	Patched 1.	0.541
ACTB	SHH	ENSCHIP00000011080	ENSCHIP00000027767	Uncharacterized protein.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.702
ACTB	SMAD4	ENSCHIP00000011080	ENSCHIP00000020573	Uncharacterized protein.	Mothers against decapentaplegic homolog.	0.774
ACTB	SMAD7	ENSCHIP00000011080	ENSCHIP00000021001	Uncharacterized protein.	Mothers against decapentaplegic homolog.	0.711