Uncharacterized protein.

Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]

Uncharacterized protein.

Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.

Uncharacterized protein.

Caspase 3; Belongs to the peptidase C14A family.

Uncharacterized protein.

C-X-C motif chemokine.

Uncharacterized protein.

Drosha ribonuclease III.

Uncharacterized protein.

FUS RNA binding protein.

Uncharacterized protein.

Interferon induced with helicase C domain 1.

Uncharacterized protein.

Interferon induced protein with tetratricopeptide repeats 3.

Uncharacterized protein.

Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]

Uncharacterized protein.

Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.

Uncharacterized protein.

Non-POU domain containing octamer binding.

Uncharacterized protein.

Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family.

Uncharacterized protein.

Signal transducer and activator of transcription.

Uncharacterized protein.

TANK binding kinase 1.

Uncharacterized protein.

Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]

Uncharacterized protein.

Toll like receptor 3; Belongs to the Toll-like receptor family.

Uncharacterized protein.

TIR domain-containing protein; Belongs to the Toll-like receptor family.

Adenosine deaminase RNA specific B2 (inactive).

C9orf72-SMCR8 complex subunit.

Adenosine deaminase RNA specific B2 (inactive).

Drosha ribonuclease III.

Adenosine deaminase RNA specific B2 (inactive).

Non-POU domain containing octamer binding.