14 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa)
	TERT	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1123 aa)
	MYB	MYB proto-oncogene, transcription factor. (640 aa)
	NKX3-1	NK3 homeobox 1. (239 aa)
	ACTB	Uncharacterized protein. (375 aa)
	CTCF	CCCTC-binding factor. (727 aa)
	SF3B3	Splicing factor 3b subunit 3. (1217 aa)
	LMO1	LIM domain only 1. (155 aa)
	AR	Androgen receptor. (891 aa)
	FOXA1	Forkhead box A1. (468 aa)
	TAL1	TAL bHLH transcription factor 1, erythroid differentiation factor. (328 aa)
	EIF4A3	Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family. (411 aa)
	GATA3	GATA binding protein 3. (467 aa)
	HOXB13	Homeobox B13. (285 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	AR	ENSCHIP00000011080	ENSCHIP00000024342	Uncharacterized protein.	Androgen receptor.	0.792
ACTB	CTCF	ENSCHIP00000011080	ENSCHIP00000011578	Uncharacterized protein.	CCCTC-binding factor.	0.523
ACTB	FOXA1	ENSCHIP00000011080	ENSCHIP00000027706	Uncharacterized protein.	Forkhead box A1.	0.421
ACTB	GATA3	ENSCHIP00000011080	ENSCHIP00000030187	Uncharacterized protein.	GATA binding protein 3.	0.673
ACTB	LEP	ENSCHIP00000011080	ENSCHIP00000021235	Uncharacterized protein.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]	0.846
ACTB	TERT	ENSCHIP00000011080	ENSCHIP00000003999	Uncharacterized protein.	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...]	0.738
AR	ACTB	ENSCHIP00000024342	ENSCHIP00000011080	Androgen receptor.	Uncharacterized protein.	0.792
AR	FOXA1	ENSCHIP00000024342	ENSCHIP00000027706	Androgen receptor.	Forkhead box A1.	0.935
AR	HOXB13	ENSCHIP00000024342	ENSCHIP00000032940	Androgen receptor.	Homeobox B13.	0.662
AR	LEP	ENSCHIP00000024342	ENSCHIP00000021235	Androgen receptor.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]	0.863
AR	NKX3-1	ENSCHIP00000024342	ENSCHIP00000006707	Androgen receptor.	NK3 homeobox 1.	0.776
CTCF	ACTB	ENSCHIP00000011578	ENSCHIP00000011080	CCCTC-binding factor.	Uncharacterized protein.	0.523
CTCF	FOXA1	ENSCHIP00000011578	ENSCHIP00000027706	CCCTC-binding factor.	Forkhead box A1.	0.739
CTCF	GATA3	ENSCHIP00000011578	ENSCHIP00000030187	CCCTC-binding factor.	GATA binding protein 3.	0.451
CTCF	TAL1	ENSCHIP00000011578	ENSCHIP00000028018	CCCTC-binding factor.	TAL bHLH transcription factor 1, erythroid differentiation factor.	0.460
EIF4A3	SF3B3	ENSCHIP00000029017	ENSCHIP00000021519	Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family.	Splicing factor 3b subunit 3.	0.589
FOXA1	ACTB	ENSCHIP00000027706	ENSCHIP00000011080	Forkhead box A1.	Uncharacterized protein.	0.421
FOXA1	AR	ENSCHIP00000027706	ENSCHIP00000024342	Forkhead box A1.	Androgen receptor.	0.935
FOXA1	CTCF	ENSCHIP00000027706	ENSCHIP00000011578	Forkhead box A1.	CCCTC-binding factor.	0.739
FOXA1	GATA3	ENSCHIP00000027706	ENSCHIP00000030187	Forkhead box A1.	GATA binding protein 3.	0.987