13 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PIPOX	Pipecolic acid and sarcosine oxidase. (392 aa)
	SHMT2	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (502 aa)
	ENSCHIP00000004162	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (515 aa)
	GLS	Glutaminase. (673 aa)
	PDK4	Protein-serine/threonine kinase. (407 aa)
	ACACA	Acetyl-CoA carboxylase alpha. (2329 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
	NR1D1	Nuclear receptor subfamily 1 group D member 1. (616 aa)
	PHGDH	D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (533 aa)
	FASN	Fatty acid synthase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. (2755 aa)
	PSAT1	Phosphoserine aminotransferase. (370 aa)
	XBP1	BZIP domain-containing protein. (261 aa)
	GNMT	Glycine N-methyltransferase. (295 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACACA	FASN	ENSCHIP00000013374	ENSCHIP00000019407	Acetyl-CoA carboxylase alpha.	Fatty acid synthase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein.	0.994
ACACA	PDK4	ENSCHIP00000013374	ENSCHIP00000011231	Acetyl-CoA carboxylase alpha.	Protein-serine/threonine kinase.	0.402
ACACA	PPARG	ENSCHIP00000013374	ENSCHIP00000015163	Acetyl-CoA carboxylase alpha.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.728
ENSCHIP00000004162	GLS	ENSCHIP00000004162	ENSCHIP00000004326	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	Glutaminase.	0.761
FASN	ACACA	ENSCHIP00000019407	ENSCHIP00000013374	Fatty acid synthase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein.	Acetyl-CoA carboxylase alpha.	0.994
FASN	PDK4	ENSCHIP00000019407	ENSCHIP00000011231	Fatty acid synthase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein.	Protein-serine/threonine kinase.	0.557
FASN	PPARG	ENSCHIP00000019407	ENSCHIP00000015163	Fatty acid synthase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.928
GLS	ENSCHIP00000004162	ENSCHIP00000004326	ENSCHIP00000004162	Glutaminase.	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	0.761
GNMT	PIPOX	ENSCHIP00000032360	ENSCHIP00000008341	Glycine N-methyltransferase.	Pipecolic acid and sarcosine oxidase.	0.944
GNMT	SHMT2	ENSCHIP00000032360	ENSCHIP00000001693	Glycine N-methyltransferase.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.957
PDK4	ACACA	ENSCHIP00000011231	ENSCHIP00000013374	Protein-serine/threonine kinase.	Acetyl-CoA carboxylase alpha.	0.402
PDK4	FASN	ENSCHIP00000011231	ENSCHIP00000019407	Protein-serine/threonine kinase.	Fatty acid synthase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein.	0.557
PDK4	PPARG	ENSCHIP00000011231	ENSCHIP00000015163	Protein-serine/threonine kinase.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.684
PHGDH	PIPOX	ENSCHIP00000019405	ENSCHIP00000008341	D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Pipecolic acid and sarcosine oxidase.	0.400
PHGDH	PSAT1	ENSCHIP00000019405	ENSCHIP00000027621	D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Phosphoserine aminotransferase.	0.999
PHGDH	SHMT2	ENSCHIP00000019405	ENSCHIP00000001693	D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.961
PIPOX	GNMT	ENSCHIP00000008341	ENSCHIP00000032360	Pipecolic acid and sarcosine oxidase.	Glycine N-methyltransferase.	0.944
PIPOX	PHGDH	ENSCHIP00000008341	ENSCHIP00000019405	Pipecolic acid and sarcosine oxidase.	D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.400
PIPOX	SHMT2	ENSCHIP00000008341	ENSCHIP00000001693	Pipecolic acid and sarcosine oxidase.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.960
PPARG	ACACA	ENSCHIP00000015163	ENSCHIP00000013374	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	Acetyl-CoA carboxylase alpha.	0.728