(20 nodes) (2018) Activated protein C reverses epigenetically sustained p66(Shc) expression in plaque-associated macrophages in diabetes. network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CD36	Uncharacterized protein; Belongs to the CD36 family. (472 aa)
	CCL2	C-C motif chemokine. (98 aa)
	DNMT1	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1591 aa)
	CD68	CD68 molecule. (335 aa)
	ACSL1	Acyl-CoA synthetase long chain family member 1. (719 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	APOE	Apolipoprotein E. (326 aa)
	LOC102174895	Uncharacterized protein. (735 aa)
	ALB	Serum albumin. (608 aa)
	PXDN	Peroxidasin. (1525 aa)
	DNMT3A	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (915 aa)
	ACTB	Uncharacterized protein. (375 aa)
	NCK1	Cytoplasmic protein. (377 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
	THBD	Thrombomodulin. (578 aa)
	NCK2	Cytoplasmic protein. (376 aa)
	SUV39H1	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (412 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
	DNMT3B	DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (872 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACSL1	CD36	ENSCHIP00000026081	ENSCHIP00000030240	Acyl-CoA synthetase long chain family member 1.	Uncharacterized protein; Belongs to the CD36 family.	0.751
ACSL1	INS	ENSCHIP00000026081	ENSCHIP00000007610	Acyl-CoA synthetase long chain family member 1.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.418
ACTB	ALB	ENSCHIP00000011080	ENSCHIP00000020234	Uncharacterized protein.	Serum albumin.	0.961
ACTB	APOE	ENSCHIP00000011080	ENSCHIP00000025098	Uncharacterized protein.	Apolipoprotein E.	0.753
ACTB	CCL2	ENSCHIP00000011080	ENSCHIP00000027804	Uncharacterized protein.	C-C motif chemokine.	0.764
ACTB	CD36	ENSCHIP00000011080	ENSCHIP00000030240	Uncharacterized protein.	Uncharacterized protein; Belongs to the CD36 family.	0.734
ACTB	CD68	ENSCHIP00000011080	ENSCHIP00000027336	Uncharacterized protein.	CD68 molecule.	0.791
ACTB	DNMT1	ENSCHIP00000011080	ENSCHIP00000027359	Uncharacterized protein.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.721
ACTB	DNMT3A	ENSCHIP00000011080	ENSCHIP00000012630	Uncharacterized protein.	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.729
ACTB	DNMT3B	ENSCHIP00000011080	ENSCHIP00000002727	Uncharacterized protein.	DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.529
ACTB	GAPDH	ENSCHIP00000011080	ENSCHIP00000025974	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.979
ACTB	IL6	ENSCHIP00000011080	ENSCHIP00000009414	Uncharacterized protein.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.919
ACTB	INS	ENSCHIP00000011080	ENSCHIP00000007610	Uncharacterized protein.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.884
ACTB	LOC102174895	ENSCHIP00000011080	ENSCHIP00000024875	Uncharacterized protein.	Uncharacterized protein.	0.776
ACTB	NCK1	ENSCHIP00000011080	ENSCHIP00000009805	Uncharacterized protein.	Cytoplasmic protein.	0.880
ACTB	NCK2	ENSCHIP00000011080	ENSCHIP00000006571	Uncharacterized protein.	Cytoplasmic protein.	0.856
ACTB	PXDN	ENSCHIP00000011080	ENSCHIP00000015493	Uncharacterized protein.	Peroxidasin.	0.962
ACTB	THBD	ENSCHIP00000011080	ENSCHIP00000007479	Uncharacterized protein.	Thrombomodulin.	0.425
ACTB	TNF	ENSCHIP00000011080	ENSCHIP00000004561	Uncharacterized protein.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.886
ALB	ACTB	ENSCHIP00000020234	ENSCHIP00000011080	Serum albumin.	Uncharacterized protein.	0.961