(15 nodes) (2019) Elongation of Mullerian ducts and connection to urogenital sinus determine the borderline of uterine and vaginal development. network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CYP26A1	Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. (497 aa)
	HOXA11	Homeobox A11. (317 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
	MEIS1	Meis homeobox 1. (465 aa)
	HOXA9	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (279 aa)
	FOXC1	Forkhead box C1. (543 aa)
	HOXA13	Homeobox A13. (388 aa)
	WT1	WT1 transcription factor. (450 aa)
	ACTB	Uncharacterized protein. (375 aa)
	MEIS2	Meis homeobox 2. (470 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (596 aa)
	LHFPL2	LHFPL tetraspan subfamily member 2. (228 aa)
	HOXA10	Homeobox A10. (413 aa)
	RDH10	Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
	CYP26B1	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ESR1	ENSCHIP00000011080	ENSCHIP00000012243	Uncharacterized protein.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.859
ACTB	FOXC1	ENSCHIP00000011080	ENSCHIP00000003416	Uncharacterized protein.	Forkhead box C1.	0.404
ACTB	TP53	ENSCHIP00000011080	ENSCHIP00000030141	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.907
ACTB	WT1	ENSCHIP00000011080	ENSCHIP00000010586	Uncharacterized protein.	WT1 transcription factor.	0.652
CYP26A1	CYP26B1	ENSCHIP00000016557	ENSCHIP00000017046	Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family.	0.910
CYP26A1	RDH10	ENSCHIP00000016557	ENSCHIP00000016296	Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family.	Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.977
CYP26B1	CYP26A1	ENSCHIP00000017046	ENSCHIP00000016557	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family.	0.910
CYP26B1	RDH10	ENSCHIP00000017046	ENSCHIP00000016296	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family.	Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.738
ESR1	ACTB	ENSCHIP00000012243	ENSCHIP00000011080	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Uncharacterized protein.	0.859
ESR1	HOXA10	ENSCHIP00000012243	ENSCHIP00000013381	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Homeobox A10.	0.617
ESR1	TP53	ENSCHIP00000012243	ENSCHIP00000030141	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.955
ESR1	WT1	ENSCHIP00000012243	ENSCHIP00000010586	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	WT1 transcription factor.	0.671
FOXC1	ACTB	ENSCHIP00000003416	ENSCHIP00000011080	Forkhead box C1.	Uncharacterized protein.	0.404
FOXC1	RDH10	ENSCHIP00000003416	ENSCHIP00000016296	Forkhead box C1.	Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.417
HOXA10	ESR1	ENSCHIP00000013381	ENSCHIP00000012243	Homeobox A10.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.617
HOXA10	HOXA11	ENSCHIP00000013381	ENSCHIP00000022695	Homeobox A10.	Homeobox A11.	0.476
HOXA10	HOXA13	ENSCHIP00000013381	ENSCHIP00000003978	Homeobox A10.	Homeobox A13.	0.532
HOXA10	HOXA9	ENSCHIP00000013381	ENSCHIP00000002117	Homeobox A10.	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family.	0.861
HOXA10	MEIS1	ENSCHIP00000013381	ENSCHIP00000033811	Homeobox A10.	Meis homeobox 1.	0.788
HOXA10	MEIS2	ENSCHIP00000013381	ENSCHIP00000011965	Homeobox A10.	Meis homeobox 2.	0.411