(13 nodes) (2019) AAV Gene Transfer with Tandem Promoter Design Prevents Anti-transgene Immunity and Provides Persistent Efficacy in Neonate Pompe Mice. network (Capra hircus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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co-expression

protein homology

Your Input:
	SP7	Sp7 transcription factor. (431 aa)
	TTN	Uncharacterized protein. (2149 aa)
	B2M	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (124 aa)
	ENSCHIP00000004646	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (118 aa)
	PGK2	Phosphoglycerate kinase. (417 aa)
	LOC102185401	SERPIN domain-containing protein; Belongs to the serpin family. (441 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	LOC102168547	Beta-2-microglobulin. (124 aa)
	SYN3	Synapsin III. (339 aa)
	PGK1	Phosphoglycerate kinase. (424 aa)
	APOE	Apolipoprotein E. (326 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	SYN2	Synapsin II. (587 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APOE	B2M	ENSCHIP00000025098	ENSCHIP00000004681	Apolipoprotein E.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	0.438
APOE	FGF2	ENSCHIP00000025098	ENSCHIP00000019134	Apolipoprotein E.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.444
APOE	GAPDH	ENSCHIP00000025098	ENSCHIP00000025974	Apolipoprotein E.	Glyceraldehyde-3-phosphate dehydrogenase.	0.770
APOE	LOC102168547	ENSCHIP00000025098	ENSCHIP00000020182	Apolipoprotein E.	Beta-2-microglobulin.	0.438
APOE	LOC102185401	ENSCHIP00000025098	ENSCHIP00000024460	Apolipoprotein E.	SERPIN domain-containing protein; Belongs to the serpin family.	0.727
B2M	APOE	ENSCHIP00000004681	ENSCHIP00000025098	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Apolipoprotein E.	0.438
B2M	ENSCHIP00000004646	ENSCHIP00000004681	ENSCHIP00000004646	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	0.545
B2M	GAPDH	ENSCHIP00000004681	ENSCHIP00000025974	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Glyceraldehyde-3-phosphate dehydrogenase.	0.871
B2M	LOC102168547	ENSCHIP00000004681	ENSCHIP00000020182	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Beta-2-microglobulin.	0.543
B2M	PGK1	ENSCHIP00000004681	ENSCHIP00000005700	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Phosphoglycerate kinase.	0.600
ENSCHIP00000004646	B2M	ENSCHIP00000004646	ENSCHIP00000004681	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	0.545
ENSCHIP00000004646	GAPDH	ENSCHIP00000004646	ENSCHIP00000025974	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Glyceraldehyde-3-phosphate dehydrogenase.	0.808
ENSCHIP00000004646	LOC102168547	ENSCHIP00000004646	ENSCHIP00000020182	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Beta-2-microglobulin.	0.545
ENSCHIP00000004646	PGK1	ENSCHIP00000004646	ENSCHIP00000005700	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Phosphoglycerate kinase.	0.479
FGF2	APOE	ENSCHIP00000019134	ENSCHIP00000025098	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Apolipoprotein E.	0.444
FGF2	GAPDH	ENSCHIP00000019134	ENSCHIP00000025974	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Glyceraldehyde-3-phosphate dehydrogenase.	0.829
GAPDH	APOE	ENSCHIP00000025974	ENSCHIP00000025098	Glyceraldehyde-3-phosphate dehydrogenase.	Apolipoprotein E.	0.770
GAPDH	B2M	ENSCHIP00000025974	ENSCHIP00000004681	Glyceraldehyde-3-phosphate dehydrogenase.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	0.871
GAPDH	ENSCHIP00000004646	ENSCHIP00000025974	ENSCHIP00000004646	Glyceraldehyde-3-phosphate dehydrogenase.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	0.808
GAPDH	FGF2	ENSCHIP00000025974	ENSCHIP00000019134	Glyceraldehyde-3-phosphate dehydrogenase.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.829