STRINGSTRING
TIPIN TIPIN TYMS TYMS CDK1 CDK1 NDC80 NDC80 PRIM1 PRIM1 CDCA7 CDCA7 CDCA8 CDCA8 HMMR HMMR RANGAP1 RANGAP1 CBX5 CBX5 G2E3 G2E3 ECT2 ECT2 CTNNB1 CTNNB1 LEF1 LEF1 KRT10 KRT10 CDC25C CDC25C EDAR EDAR NUBP2 NUBP2 E2F8 E2F8 CLSPN CLSPN CKAP2 CKAP2 AURKB AURKB CCNE2 CCNE2 GLB1L3 GLB1L3 CKS2 CKS2 TUBB4B TUBB4B KIF2C KIF2C ATAD2 ATAD2 NUF2 NUF2 SOX9 SOX9 COL1A1 COL1A1 BMP4 BMP4 PSRC1 PSRC1 HJURP HJURP AXIN2 AXIN2 CDC20 CDC20 GMNN GMNN PIMREG PIMREG HELLS HELLS SLBP SLBP UBR7 UBR7 ALB ALB SMC4 SMC4 RRM1 RRM1 CDCA2 CDCA2 UHRF1 UHRF1 CKAP5 CKAP5 KIF11 KIF11 MCM4 MCM4 CENPE CENPE CASP8AP2 CASP8AP2 CCNA2 CCNA2 DLGAP5 DLGAP5 MCM6 MCM6 ANLN ANLN LOX LOX POLA1 POLA1 GINS2 GINS2 CHAF1B CHAF1B UBE2C UBE2C USP1 USP1 PCNA PCNA NCAPD2 NCAPD2 GAS2L3 GAS2L3 FGF20 FGF20 CDC45 CDC45 DKK1 DKK1 KRT14 KRT14 CCNB2 CCNB2 NASP NASP DSCC1 DSCC1 GLB1 GLB1 RAD51AP1 RAD51AP1 PTCH1 PTCH1 CTCF CTCF LBR LBR ACTB ACTB BIRC5 BIRC5 TACC3 TACC3 CDCA3 CDCA3 EXO1 EXO1 TOP2A TOP2A CENPF CENPF KIF20B KIF20B WDR76 WDR76 BUB1 BUB1 MCM5 MCM5 TMPO TMPO SOX2 SOX2 KRT17 KRT17 CENPA CENPA LOC108633924 LOC108633924 RRM2 RRM2 NEK2 NEK2 CDC6 CDC6 FEN1 FEN1 RFC2 RFC2 NUSAP1 NUSAP1 TWIST2 TWIST2 CDKN1A CDKN1A PDGFRA PDGFRA ANP32E ANP32E KIF23 KIF23
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TIPINTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (289 aa)
TYMSThymidylate synthetase. (355 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (312 aa)
NDC80NDC80 kinetochore complex component. (642 aa)
PRIM1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (401 aa)
CDCA7Cell division cycle associated 7. (450 aa)
CDCA8Cell division cycle associated 8. (280 aa)
HMMRHyaluronan mediated motility receptor. (715 aa)
RANGAP1Ran GTPase activating protein 1. (585 aa)
CBX5Chromobox 5. (191 aa)
G2E3G2/M-phase specific E3 ubiquitin protein ligase. (703 aa)
ECT2Epithelial cell transforming 2. (913 aa)
CTNNB1Catenin beta 1. (781 aa)
LEF1HMG box domain-containing protein. (430 aa)
KRT10Keratin 10; Belongs to the intermediate filament family. (564 aa)
CDC25CCell division cycle 25C. (452 aa)
EDAREctodysplasin A receptor. (441 aa)
NUBP2Cytosolic Fe-S cluster assembly factor NUBP2; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily. (273 aa)
E2F8E2F transcription factor 8. (866 aa)
CLSPNClaspin. (1339 aa)
CKAP2Cytoskeleton associated protein 2. (682 aa)
AURKBAurora kinase B; Belongs to the protein kinase superfamily. (344 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
GLB1L3Beta-galactosidase. (664 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
TUBB4BTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
KIF2CKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (721 aa)
ATAD2ATPase family AAA domain containing 2. (1385 aa)
NUF2NUF2 component of NDC80 kinetochore complex. (465 aa)
SOX9SRY-box transcription factor 9. (525 aa)
COL1A1Collagen type I alpha 1 chain. (1463 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
PSRC1Proline and serine rich coiled-coil 1. (326 aa)
HJURPHolliday junction recognition protein. (694 aa)
AXIN2Axin 2. (844 aa)
CDC20WD_REPEATS_REGION domain-containing protein. (499 aa)
GMNNGeminin DNA replication inhibitor. (186 aa)
PIMREGPICALM interacting mitotic regulator. (239 aa)
HELLSHelicase, lymphoid specific. (824 aa)
SLBPStem-loop binding protein. (275 aa)
UBR7UBR-type domain-containing protein. (425 aa)
ALBSerum albumin. (608 aa)
SMC4Structural maintenance of chromosomes protein. (1288 aa)
RRM1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (791 aa)
CDCA2Cell division cycle associated 2. (1008 aa)
UHRF1Ubiquitin like with PHD and ring finger domains 1. (786 aa)
CKAP5Cytoskeleton associated protein 5. (2040 aa)
KIF11Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1055 aa)
MCM4DNA helicase; Belongs to the MCM family. (851 aa)
CENPECentromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2431 aa)
CASP8AP2Caspase 8 associated protein 2. (1971 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (430 aa)
DLGAP5DLG associated protein 5. (843 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
ANLNAnillin actin binding protein. (1148 aa)
LOXLysyl oxidase. (418 aa)
POLA1DNA polymerase. (1468 aa)
GINS2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa)
CHAF1BChromatin assembly factor 1 subunit B. (567 aa)
UBE2CUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (172 aa)
USP1Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (782 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
NCAPD2Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1396 aa)
GAS2L3Growth arrest specific 2 like 3. (693 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
CDC45Cell division cycle 45. (524 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (262 aa)
KRT14Keratin 14; Belongs to the intermediate filament family. (514 aa)
CCNB2Cyclin B2; Belongs to the cyclin family. (398 aa)
NASPNuclear autoantigenic sperm protein. (770 aa)
DSCC1Uncharacterized protein. (388 aa)
GLB1Beta-galactosidase. (646 aa)
RAD51AP1RAD51 associated protein 1. (326 aa)
PTCH1Patched 1. (1453 aa)
CTCFCCCTC-binding factor. (727 aa)
LBRLamin B receptor. (647 aa)
ACTBUncharacterized protein. (375 aa)
BIRC5Uncharacterized protein. (142 aa)
TACC3TACC_C domain-containing protein. (743 aa)
CDCA3Cell division cycle associated 3. (265 aa)
EXO1Exonuclease 1. (835 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1538 aa)
CENPFCentromere protein F. (3055 aa)
KIF20BKinesin family member 20B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1761 aa)
WDR76WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Belongs to the WD repeat DDB2/WDR76 family. (626 aa)
BUB1BUB1 mitotic checkpoint serine/threonine kinase. (1090 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
TMPOThymopoietin. (689 aa)
SOX2HMG box domain-containing protein. (320 aa)
KRT17Keratin 17; Belongs to the intermediate filament family. (448 aa)
CENPACentromere protein A. (138 aa)
LOC108633924Histone domain-containing protein. (138 aa)
RRM2Ribonucleotide reductase regulatory subunit M2. (389 aa)
NEK2NIMA related kinase 2. (445 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (562 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
RFC2Replication factor C subunit 2. (352 aa)
NUSAP1Uncharacterized protein. (431 aa)
TWIST2Twist family bHLH transcription factor 2. (160 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (161 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1108 aa)
ANP32EAcidic nuclear phosphoprotein 32 family member E. (231 aa)
KIF23Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (966 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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