STRINGSTRING
PPARG PPARG WNT8A WNT8A CTNNA1 CTNNA1 SPAG8 SPAG8 ATP10A ATP10A HOXC12 HOXC12 RXFP2 RXFP2 FABP4 FABP4 ADAMTS3 ADAMTS3 PPARA PPARA MELK MELK LRRTM2 LRRTM2 HOXC13 HOXC13 HOXC11 HOXC11 CDC23 CDC23 BPIFA1 BPIFA1 SP3 SP3 MED1 MED1 RXRA RXRA GNE GNE BPIFB3 BPIFB3 KIF20A KIF20A HOXB9 HOXB9 WDR92 WDR92 VRTN VRTN DNAJC18 DNAJC18 RECK RECK DIS3L2 DIS3L2 WNT11 WNT11 PKD2L2 PKD2L2 BRD8 BRD8 BMP4 BMP4 HOXA11 HOXA11 BPIFB6 BPIFB6 BPIFA3 BPIFA3 CDH8 CDH8 ANGPTL8 ANGPTL8 PRKAA1 PRKAA1 BPIFB1 BPIFB1 FAM13B FAM13B SPATA24 SPATA24 RNF38 RNF38 CIB4 CIB4 CLTA CLTA BPIFB4 BPIFB4 PROKR1 PROKR1 PPP1CC PPP1CC NME5 NME5 SULF2 SULF2 INSR INSR PRNP PRNP FABP3 FABP3 PPARD PPARD ADRB3 ADRB3 HOXC6 HOXC6 SP9 SP9 KLF11 KLF11 THRA THRA INS INS EYA2 EYA2 STING1 STING1 NPR2 NPR2 ALX4 ALX4 GFRA3 GFRA3 HINT2 HINT2 CCIN CCIN SIL1 SIL1 TSPAN8 TSPAN8 ETAA1 ETAA1 BPIFB2 BPIFB2 TRPM8 TRPM8 HOXB13 HOXB13
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
CTNNA1Catenin alpha 1. (1018 aa)
SPAG8Uncharacterized protein. (368 aa)
ATP10APhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1514 aa)
HOXC12Homeobox C12. (278 aa)
RXFP2Relaxin family peptide receptor 2. (725 aa)
FABP4Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
ADAMTS3ADAM metallopeptidase with thrombospondin type 1 motif 3. (1202 aa)
PPARAPeroxisome proliferator activated receptor alpha. (470 aa)
MELKNon-specific serine/threonine protein kinase. (650 aa)
LRRTM2Leucine rich repeat transmembrane neuronal 2. (517 aa)
HOXC13Homeobox C13. (330 aa)
HOXC11Homeobox C11. (304 aa)
CDC23Cell division cycle 23. (597 aa)
BPIFA1BPI fold containing family A member 1. (229 aa)
SP3Sp3 transcription factor. (778 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1577 aa)
RXRANR LBD domain-containing protein. (106 aa)
GNEGlucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase. (722 aa)
BPIFB3BPI fold containing family B member 3. (480 aa)
KIF20AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (888 aa)
HOXB9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (250 aa)
WDR92WD repeat domain 92. (357 aa)
VRTNVertebrae development associated. (689 aa)
DNAJC18DnaJ heat shock protein family (Hsp40) member C18. (358 aa)
RECKReversion inducing cysteine rich protein with kazal motifs. (971 aa)
DIS3L2DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...] (882 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
PKD2L2Polycystin 2 like 2, transient receptor potential cation channel. (596 aa)
BRD8Bromodomain containing 8. (1216 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
HOXA11Homeobox A11. (317 aa)
BPIFB6BPI fold containing family B member 6. (454 aa)
BPIFA3BPI fold containing family A member 3. (238 aa)
CDH8Cadherin 8; Cadherins are calcium-dependent cell adhesion proteins. (799 aa)
ANGPTL8Angiopoietin like 8. (199 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
BPIFB1BPI fold containing family B member 1. (514 aa)
FAM13BFamily with sequence similarity 13 member B. (910 aa)
SPATA24Spermatogenesis associated 24. (205 aa)
RNF38Ring finger protein 38. (432 aa)
CIB4Calcium and integrin binding family member 4. (181 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (243 aa)
BPIFB4BPI fold containing family B member 4. (596 aa)
PROKR1Prokineticin receptor 1; Belongs to the G-protein coupled receptor 1 family. (393 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (314 aa)
NME5NME/NM23 family member 5; Belongs to the NDK family. (209 aa)
SULF2Sulfatase 2. (864 aa)
INSRTyrosine-protein kinase receptor. (1365 aa)
PRNPMajor prion protein; Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan s [...] (256 aa)
FABP3Heart-type fatty acid binding protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (133 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
ADRB3Beta-3 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta- 3 is involved in the regulation of lipolysis and thermogenesis. (430 aa)
HOXC6Homeobox C6. (235 aa)
SP9Sp9 transcription factor. (481 aa)
KLF11Kruppel like factor 11. (505 aa)
THRAThyroid hormone receptor alpha. (511 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (552 aa)
STING1Transmembrane protein 173. (378 aa)
NPR2Guanylate cyclase. (1047 aa)
ALX4ALX homeobox 4. (397 aa)
GFRA3GDNF family receptor alpha 3. (379 aa)
HINT2Histidine triad nucleotide binding protein 2. (163 aa)
CCINCalicin. (588 aa)
SIL1SIL1 nucleotide exchange factor. (486 aa)
TSPAN8Tetraspanin. (276 aa)
ETAA1ETAA1 activator of ATR kinase. (903 aa)
BPIFB2BPI fold containing family B member 2. (459 aa)
TRPM8Transient receptor potential cation channel subfamily M member 8. (1099 aa)
HOXB13Homeobox B13. (285 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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