STRINGSTRING
LRP5 LRP5 AXIN2 AXIN2 BMP4 BMP4 COL1A1 COL1A1 GLB1L3 GLB1L3 SHH SHH LEF1 LEF1 CTNNB1 CTNNB1 SP7 SP7 BABAM2 BABAM2 FGFR3 FGFR3 PTH PTH NOG NOG BMP7 BMP7 TGFB1 TGFB1 GDF5 GDF5 ACTB ACTB GLB1 GLB1 DKK1 DKK1 RUNX2 RUNX2 WNT3A WNT3A IGF1 IGF1 GRHL3 GRHL3 SOST SOST
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1615 aa)
AXIN2Axin 2. (844 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
COL1A1Collagen type I alpha 1 chain. (1463 aa)
GLB1L3Beta-galactosidase. (664 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
LEF1HMG box domain-containing protein. (430 aa)
CTNNB1Catenin beta 1. (781 aa)
SP7Sp7 transcription factor. (431 aa)
BABAM2BRISC and BRCA1 A complex member 2. (383 aa)
FGFR3Receptor protein-tyrosine kinase. (710 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
GDF5Growth differentiation factor 5. (499 aa)
ACTBUncharacterized protein. (375 aa)
GLB1Beta-galactosidase. (646 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (262 aa)
RUNX2RUNX family transcription factor 2. (585 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (188 aa)
GRHL3Grainyhead like transcription factor 3. (600 aa)
SOSTSclerostin. (212 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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