(16 nodes) (2019) Phosphoglycerate dehydrogenase promotes pancreatic cancer development by interacting with eIF4A1 and eIF4E. network (Capra hircus)

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Your Input:
	SHMT2	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (502 aa)
	EIF4E	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
	FOXM1	Fork-head domain-containing protein. (763 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	EIF4A1	Eukaryotic translation initiation factor 4A1; Belongs to the DEAD box helicase family. (406 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
	DDX31	RNA helicase. (733 aa)
	DDX18	RNA helicase. (763 aa)
	EIF4EBP1	Uncharacterized protein. (118 aa)
	PHGDH	D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (533 aa)
	DDX10	RNA helicase. (878 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (596 aa)
	SHMT1	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (484 aa)
	DDX55	RNA helicase. (601 aa)
	EIF4A2	Eukaryotic translation initiation factor 4A2; Belongs to the DEAD box helicase family. (408 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTNNB1	EIF4E	ENSCHIP00000031016	ENSCHIP00000005408	Catenin beta 1.	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	0.442
CTNNB1	ESR1	ENSCHIP00000031016	ENSCHIP00000012243	Catenin beta 1.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.850
CTNNB1	FOXM1	ENSCHIP00000031016	ENSCHIP00000030834	Catenin beta 1.	Fork-head domain-containing protein.	0.875
CTNNB1	KRAS	ENSCHIP00000031016	ENSCHIP00000032733	Catenin beta 1.	KRAS proto-oncogene, GTPase.	0.809
CTNNB1	MTOR	ENSCHIP00000031016	ENSCHIP00000021872	Catenin beta 1.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.517
CTNNB1	PHGDH	ENSCHIP00000031016	ENSCHIP00000019405	Catenin beta 1.	D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.482
DDX10	DDX18	ENSCHIP00000013908	ENSCHIP00000020719	RNA helicase.	RNA helicase.	0.986
DDX10	DDX31	ENSCHIP00000013908	ENSCHIP00000021799	RNA helicase.	RNA helicase.	0.847
DDX10	DDX55	ENSCHIP00000013908	ENSCHIP00000022465	RNA helicase.	RNA helicase.	0.719
DDX10	EIF4E	ENSCHIP00000013908	ENSCHIP00000005408	RNA helicase.	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	0.678
DDX18	DDX10	ENSCHIP00000020719	ENSCHIP00000013908	RNA helicase.	RNA helicase.	0.986
DDX18	DDX31	ENSCHIP00000020719	ENSCHIP00000021799	RNA helicase.	RNA helicase.	0.838
DDX18	DDX55	ENSCHIP00000020719	ENSCHIP00000022465	RNA helicase.	RNA helicase.	0.895
DDX18	EIF4A2	ENSCHIP00000020719	ENSCHIP00000009579	RNA helicase.	Eukaryotic translation initiation factor 4A2; Belongs to the DEAD box helicase family.	0.411
DDX18	EIF4E	ENSCHIP00000020719	ENSCHIP00000005408	RNA helicase.	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	0.709
DDX31	DDX10	ENSCHIP00000021799	ENSCHIP00000013908	RNA helicase.	RNA helicase.	0.847
DDX31	DDX18	ENSCHIP00000021799	ENSCHIP00000020719	RNA helicase.	RNA helicase.	0.838
DDX31	DDX55	ENSCHIP00000021799	ENSCHIP00000022465	RNA helicase.	RNA helicase.	0.755
DDX31	EIF4E	ENSCHIP00000021799	ENSCHIP00000005408	RNA helicase.	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	0.691
DDX55	DDX10	ENSCHIP00000022465	ENSCHIP00000013908	RNA helicase.	RNA helicase.	0.719