(13 nodes) (2019) TFAP2C-Activated MALAT1 Modulates the Chemoresistance of Docetaxel-Resistant Lung Adenocarcinoma Cells. network (Capra hircus)

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second shell of interactors

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Your Input:
	CTNNB1	Catenin beta 1. (781 aa)
	SRC	Tyrosine-protein kinase. (538 aa)
	AGO2	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (860 aa)
	E2F3	E2F_TDP domain-containing protein. (460 aa)
	SOX2	HMG box domain-containing protein. (320 aa)
	CASP6	Caspase 6; Belongs to the peptidase C14A family. (275 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (275 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	PXDN	Peroxidasin. (1525 aa)
	TFAP2C	Transcription factor AP-2 gamma. (450 aa)
	ZEB1	Zinc finger E-box binding homeobox 1. (1127 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	MMUT	Methylmalonyl-CoA mutase. (771 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO2	CASP3	ENSCHIP00000006557	ENSCHIP00000011490	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Caspase 3; Belongs to the peptidase C14A family.	0.538
AGO2	CTNNB1	ENSCHIP00000006557	ENSCHIP00000031016	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Catenin beta 1.	0.568
AGO2	E2F3	ENSCHIP00000006557	ENSCHIP00000007013	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	E2F_TDP domain-containing protein.	0.457
AGO2	GAPDH	ENSCHIP00000006557	ENSCHIP00000025974	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Glyceraldehyde-3-phosphate dehydrogenase.	0.824
AGO2	MMUT	ENSCHIP00000006557	ENSCHIP00000027222	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Methylmalonyl-CoA mutase.	0.905
AGO2	PXDN	ENSCHIP00000006557	ENSCHIP00000015493	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Peroxidasin.	0.637
AGO2	ZEB1	ENSCHIP00000006557	ENSCHIP00000015942	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Zinc finger E-box binding homeobox 1.	0.643
CASP3	AGO2	ENSCHIP00000011490	ENSCHIP00000006557	Caspase 3; Belongs to the peptidase C14A family.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.538
CASP3	CASP6	ENSCHIP00000011490	ENSCHIP00000008928	Caspase 3; Belongs to the peptidase C14A family.	Caspase 6; Belongs to the peptidase C14A family.	0.641
CASP3	CTNNB1	ENSCHIP00000011490	ENSCHIP00000031016	Caspase 3; Belongs to the peptidase C14A family.	Catenin beta 1.	0.963
CASP3	GAPDH	ENSCHIP00000011490	ENSCHIP00000025974	Caspase 3; Belongs to the peptidase C14A family.	Glyceraldehyde-3-phosphate dehydrogenase.	0.943
CASP3	MMUT	ENSCHIP00000011490	ENSCHIP00000027222	Caspase 3; Belongs to the peptidase C14A family.	Methylmalonyl-CoA mutase.	0.717
CASP3	PXDN	ENSCHIP00000011490	ENSCHIP00000015493	Caspase 3; Belongs to the peptidase C14A family.	Peroxidasin.	0.971
CASP3	SOX2	ENSCHIP00000011490	ENSCHIP00000007702	Caspase 3; Belongs to the peptidase C14A family.	HMG box domain-containing protein.	0.720
CASP3	SRC	ENSCHIP00000011490	ENSCHIP00000002619	Caspase 3; Belongs to the peptidase C14A family.	Tyrosine-protein kinase.	0.760
CASP3	ZEB1	ENSCHIP00000011490	ENSCHIP00000015942	Caspase 3; Belongs to the peptidase C14A family.	Zinc finger E-box binding homeobox 1.	0.566
CASP6	CASP3	ENSCHIP00000008928	ENSCHIP00000011490	Caspase 6; Belongs to the peptidase C14A family.	Caspase 3; Belongs to the peptidase C14A family.	0.641
CASP6	CTNNB1	ENSCHIP00000008928	ENSCHIP00000031016	Caspase 6; Belongs to the peptidase C14A family.	Catenin beta 1.	0.450
CASP6	GAPDH	ENSCHIP00000008928	ENSCHIP00000025974	Caspase 6; Belongs to the peptidase C14A family.	Glyceraldehyde-3-phosphate dehydrogenase.	0.432
CASP6	PXDN	ENSCHIP00000008928	ENSCHIP00000015493	Caspase 6; Belongs to the peptidase C14A family.	Peroxidasin.	0.491