(47 nodes) (2019) The HGF-MET axis coordinates liver cancer metabolism and autophagy for chemotherapeutic resistance. network (Capra hircus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

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gene fusions

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textmining

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protein homology

Your Input:
	PKM	Pyruvate kinase; Belongs to the pyruvate kinase family. (531 aa)
	PDHA1	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (393 aa)
	HK1	Hexokinase 1. (945 aa)
	IDH2	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa)
	PKLR	Pyruvate kinase; Belongs to the pyruvate kinase family. (575 aa)
	FLT3	Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (992 aa)
	SLC7A8	Solute carrier family 7 member 8. (528 aa)
	GLS	Glutaminase. (673 aa)
	SLC2A2	Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (510 aa)
	HGF	Hepatocyte growth factor; Belongs to the peptidase S1 family. (814 aa)
	HKDC1	Hexokinase domain containing 1. (918 aa)
	FGFR1	Fibroblast growth factor receptor. (860 aa)
	SLC8A3	Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (928 aa)
	SLC2A3	MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
	HK2	Hexokinase 2. (917 aa)
	PDHX	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (501 aa)
	ACTB	Uncharacterized protein. (375 aa)
	FLT4	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1365 aa)
	ATG13	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (517 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (900 aa)
	SLC2A1	MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (500 aa)
	RUBCN	Rubicon autophagy regulator. (986 aa)
	RB1CC1	RB1 inducible coiled-coil 1. (1589 aa)
	IDH1	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
	LDH-A	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (361 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (774 aa)
	RRAGB	Ras related GTP binding B. (374 aa)
	ATG7	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (722 aa)
	ULK1	Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (1055 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
	SLC2A4	MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
	DLAT	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (647 aa)
	RPTOR	Regulatory associated protein of MTOR complex 1. (1342 aa)
	SLC1A5	Amino acid transporter. (530 aa)
	BECN1	Uncharacterized protein. (448 aa)
	SLC8A1	Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (650 aa)
	KIT	Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (974 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	SQSTM1	Sequestosome 1. (440 aa)
	ATG12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
	PDGFRB	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
	HK3	Hexokinase 3. (924 aa)
	GLUL	Glutamine synthetase. (373 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	UVRAG	UV radiation resistance associated. (699 aa)
	ATG16L1	Autophagy related 16 like 1. (607 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ATG12	ENSCHIP00000011080	ENSCHIP00000029307	Uncharacterized protein.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.731
ACTB	ATG13	ENSCHIP00000011080	ENSCHIP00000013146	Uncharacterized protein.	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily.	0.502
ACTB	ATG16L1	ENSCHIP00000011080	ENSCHIP00000032565	Uncharacterized protein.	Autophagy related 16 like 1.	0.574
ACTB	ATG5	ENSCHIP00000011080	ENSCHIP00000021333	Uncharacterized protein.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.863
ACTB	ATG7	ENSCHIP00000011080	ENSCHIP00000020049	Uncharacterized protein.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	0.807
ACTB	BECN1	ENSCHIP00000011080	ENSCHIP00000024304	Uncharacterized protein.	Uncharacterized protein.	0.886
ACTB	BRAF	ENSCHIP00000011080	ENSCHIP00000019379	Uncharacterized protein.	B-Raf proto-oncogene, serine/threonine kinase.	0.746
ACTB	CTNNB1	ENSCHIP00000011080	ENSCHIP00000031016	Uncharacterized protein.	Catenin beta 1.	0.906
ACTB	FGFR1	ENSCHIP00000011080	ENSCHIP00000007607	Uncharacterized protein.	Fibroblast growth factor receptor.	0.691
ACTB	FLT3	ENSCHIP00000011080	ENSCHIP00000002806	Uncharacterized protein.	Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.550
ACTB	GAPDH	ENSCHIP00000011080	ENSCHIP00000025974	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.979
ACTB	GLUL	ENSCHIP00000011080	ENSCHIP00000030828	Uncharacterized protein.	Glutamine synthetase.	0.599
ACTB	HGF	ENSCHIP00000011080	ENSCHIP00000005606	Uncharacterized protein.	Hepatocyte growth factor; Belongs to the peptidase S1 family.	0.717
ACTB	HK1	ENSCHIP00000011080	ENSCHIP00000000719	Uncharacterized protein.	Hexokinase 1.	0.685
ACTB	HK2	ENSCHIP00000011080	ENSCHIP00000009707	Uncharacterized protein.	Hexokinase 2.	0.728
ACTB	HK3	ENSCHIP00000011080	ENSCHIP00000029968	Uncharacterized protein.	Hexokinase 3.	0.585
ACTB	HKDC1	ENSCHIP00000011080	ENSCHIP00000007027	Uncharacterized protein.	Hexokinase domain containing 1.	0.584
ACTB	IDH1	ENSCHIP00000011080	ENSCHIP00000019250	Uncharacterized protein.	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.460
ACTB	IDH2	ENSCHIP00000011080	ENSCHIP00000001938	Uncharacterized protein.	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.468
ACTB	KIT	ENSCHIP00000011080	ENSCHIP00000025751	Uncharacterized protein.	Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...]	0.719