(21 nodes) (2019) The balance of Bmp6 and Wnt10b regulates the telogen-anagen transition of hair follicles. network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
	CD34	Uncharacterized protein. (384 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	WNT10B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	SOX4	SRY-box transcription factor 4. (504 aa)
	KRT14	Keratin 14; Belongs to the intermediate filament family. (514 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
	KRT15	Keratin 15; Belongs to the intermediate filament family. (453 aa)
	SMAD4	Mothers against decapentaplegic homolog. (513 aa)
	NFATC1	Nuclear factor of activated T cells 1. (1002 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (443 aa)
	KRT19	Keratin 19; Belongs to the intermediate filament family. (399 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
	KRT10	Keratin 10; Belongs to the intermediate filament family. (564 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	BMP6	Bone morphogenetic protein 6. (496 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	BMP6	ENSCHIP00000023678	ENSCHIP00000032648	Bone morphogenetic protein 4.	Bone morphogenetic protein 6.	0.967
BMP4	CD34	ENSCHIP00000023678	ENSCHIP00000002645	Bone morphogenetic protein 4.	Uncharacterized protein.	0.672
BMP4	CTNNB1	ENSCHIP00000023678	ENSCHIP00000031016	Bone morphogenetic protein 4.	Catenin beta 1.	0.800
BMP4	NOG	ENSCHIP00000023678	ENSCHIP00000005264	Bone morphogenetic protein 4.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.999
BMP4	SHH	ENSCHIP00000023678	ENSCHIP00000027767	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.909
BMP4	SMAD4	ENSCHIP00000023678	ENSCHIP00000020573	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.949
BMP4	TGFB1	ENSCHIP00000023678	ENSCHIP00000008885	Bone morphogenetic protein 4.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.495
BMP4	TP53	ENSCHIP00000023678	ENSCHIP00000030141	Bone morphogenetic protein 4.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.447
BMP4	WNT1	ENSCHIP00000023678	ENSCHIP00000020293	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.618
BMP4	WNT10B	ENSCHIP00000023678	ENSCHIP00000007408	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.720
BMP4	WNT3A	ENSCHIP00000023678	ENSCHIP00000015590	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.874
BMP4	WNT5A	ENSCHIP00000023678	ENSCHIP00000015533	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.731
BMP6	BMP4	ENSCHIP00000032648	ENSCHIP00000023678	Bone morphogenetic protein 6.	Bone morphogenetic protein 4.	0.967
BMP6	CTNNB1	ENSCHIP00000032648	ENSCHIP00000031016	Bone morphogenetic protein 6.	Catenin beta 1.	0.459
BMP6	NOG	ENSCHIP00000032648	ENSCHIP00000005264	Bone morphogenetic protein 6.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.993
BMP6	SHH	ENSCHIP00000032648	ENSCHIP00000027767	Bone morphogenetic protein 6.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.415
BMP6	SMAD4	ENSCHIP00000032648	ENSCHIP00000020573	Bone morphogenetic protein 6.	Mothers against decapentaplegic homolog.	0.795
BMP6	TGFB3	ENSCHIP00000032648	ENSCHIP00000001127	Bone morphogenetic protein 6.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.576
BMP6	WNT10B	ENSCHIP00000032648	ENSCHIP00000007408	Bone morphogenetic protein 6.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.523
BMP6	WNT3A	ENSCHIP00000032648	ENSCHIP00000015590	Bone morphogenetic protein 6.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.418