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BMP6 BMP6 HOXA5 HOXA5 HOXB6 HOXB6 COL2A1 COL2A1 INS INS TGFB1 TGFB1 ACTB ACTB HOXB3 HOXB3 PPARG PPARG RUNX2 RUNX2 PXDN PXDN HOXB7 HOXB7 DCN DCN ALB ALB ACAN ACAN COL1A1 COL1A1 SOX9 SOX9 HOXA7 HOXA7 HOXB5 HOXB5 TP53 TP53 HOXB4 HOXB4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BMP6Bone morphogenetic protein 6. (496 aa)
HOXA5Homeobox A5. (270 aa)
HOXB6Homeobox B6. (224 aa)
COL2A1Collagen type II alpha 1 chain. (1259 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ACTBUncharacterized protein. (375 aa)
HOXB3Homeobox B3. (426 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
RUNX2RUNX family transcription factor 2. (585 aa)
PXDNPeroxidasin. (1525 aa)
HOXB7Homeobox B7. (217 aa)
DCNDecorin; May affect the rate of fibrils formation. (360 aa)
ALBSerum albumin. (608 aa)
ACANAggrecan. (2402 aa)
COL1A1Collagen type I alpha 1 chain. (1463 aa)
SOX9SRY-box transcription factor 9. (525 aa)
HOXA7Homeobox A7. (239 aa)
HOXB5Homeobox B5. (269 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
HOXB4Homeobox B4. (251 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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