40 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
	PCK1	Phosphoenolpyruvate carboxykinase 1. (622 aa)
	FABP4	Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
	BIRC6	Baculoviral IAP repeat containing 6. (4878 aa)
	PDE3B	Phosphodiesterase. (1115 aa)
	PGK1	Phosphoglycerate kinase. (424 aa)
	THRSP	Thyroid hormone responsive. (150 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
	IL10RA	Interleukin 10 receptor subunit alpha. (580 aa)
	ELOVL5	Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...] (299 aa)
	HERC1	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1. (4856 aa)
	ITCH	E3 ubiquitin-protein ligase. (874 aa)
	HMBS	Hydroxymethylbilane synthase. (348 aa)
	ACTB	Uncharacterized protein. (375 aa)
	ACACA	Acetyl-CoA carboxylase alpha. (2329 aa)
	API5	Apoptosis inhibitor 5. (524 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
	HERC2	HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4836 aa)
	DCN	Decorin; May affect the rate of fibrils formation. (360 aa)
	FASN	Fatty acid synthase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. (2755 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
	YWHAZ	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide; Belongs to the 14-3-3 family. (245 aa)
	LCP2	Lymphocyte cytosolic protein 2. (527 aa)
	EIF2B2	Eukaryotic translation initiation factor 2B subunit beta; Belongs to the eIF-2B alpha/beta/delta subunits family. (351 aa)
	HUWE1	HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1. (4346 aa)
	UBR5	Ubiquitin protein ligase E3 component n-recognin 5. (2801 aa)
	GCG	Glucagon. (180 aa)
	COL1A1	Collagen type I alpha 1 chain. (1463 aa)
	FBN1	Fibrillin 1. (2860 aa)
	FN1	Fibronectin 1. (2478 aa)
	RPL13A	Uncharacterized protein; Belongs to the universal ribosomal protein uL13 family. (203 aa)
	COL4A1	Collagen type IV alpha 1 chain. (1608 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	DOCK2	DHR-1 domain-containing protein; Belongs to the DOCK family. (846 aa)
	VAPB	VAMP associated protein B and C. (243 aa)
	PCK2	Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa)
	COL1A2	Collagen type I alpha 2 chain. (1128 aa)
	COL4A2	Collagen type IV alpha 2 chain. (1607 aa)
	GUSB	Uncharacterized protein. (659 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACACA	ACTB	ENSCHIP00000013374	ENSCHIP00000011080	Acetyl-CoA carboxylase alpha.	Uncharacterized protein.	0.512
ACACA	ELOVL5	ENSCHIP00000013374	ENSCHIP00000010413	Acetyl-CoA carboxylase alpha.	Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...]	0.641
ACACA	FABP4	ENSCHIP00000013374	ENSCHIP00000004118	Acetyl-CoA carboxylase alpha.	Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	0.853
ACACA	FASN	ENSCHIP00000013374	ENSCHIP00000019407	Acetyl-CoA carboxylase alpha.	Fatty acid synthase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein.	0.994
ACACA	GAPDH	ENSCHIP00000013374	ENSCHIP00000025974	Acetyl-CoA carboxylase alpha.	Glyceraldehyde-3-phosphate dehydrogenase.	0.498
ACACA	INS	ENSCHIP00000013374	ENSCHIP00000007610	Acetyl-CoA carboxylase alpha.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.622
ACACA	LEP	ENSCHIP00000013374	ENSCHIP00000021235	Acetyl-CoA carboxylase alpha.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]	0.560
ACACA	PCK1	ENSCHIP00000013374	ENSCHIP00000001941	Acetyl-CoA carboxylase alpha.	Phosphoenolpyruvate carboxykinase 1.	0.563
ACACA	PCK2	ENSCHIP00000013374	ENSCHIP00000029632	Acetyl-CoA carboxylase alpha.	Phosphoenolpyruvate carboxykinase 2, mitochondrial.	0.585
ACACA	PPARG	ENSCHIP00000013374	ENSCHIP00000015163	Acetyl-CoA carboxylase alpha.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.728
ACACA	THRSP	ENSCHIP00000013374	ENSCHIP00000006576	Acetyl-CoA carboxylase alpha.	Thyroid hormone responsive.	0.701
ACTB	ACACA	ENSCHIP00000011080	ENSCHIP00000013374	Uncharacterized protein.	Acetyl-CoA carboxylase alpha.	0.512
ACTB	COL1A1	ENSCHIP00000011080	ENSCHIP00000023918	Uncharacterized protein.	Collagen type I alpha 1 chain.	0.776
ACTB	COL1A2	ENSCHIP00000011080	ENSCHIP00000031191	Uncharacterized protein.	Collagen type I alpha 2 chain.	0.563
ACTB	DCN	ENSCHIP00000011080	ENSCHIP00000018727	Uncharacterized protein.	Decorin; May affect the rate of fibrils formation.	0.500
ACTB	FABP4	ENSCHIP00000011080	ENSCHIP00000004118	Uncharacterized protein.	Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	0.656
ACTB	FASN	ENSCHIP00000011080	ENSCHIP00000019407	Uncharacterized protein.	Fatty acid synthase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein.	0.723
ACTB	GAPDH	ENSCHIP00000011080	ENSCHIP00000025974	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.979
ACTB	GCG	ENSCHIP00000011080	ENSCHIP00000023896	Uncharacterized protein.	Glucagon.	0.658
ACTB	GUSB	ENSCHIP00000011080	ENSCHIP00000032959	Uncharacterized protein.	Uncharacterized protein.	0.754