31 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	PC	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1187 aa)
	HEY1	Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
	ASNS	Asparagine synthetase [glutamine-hydrolyzing]. (561 aa)
	IDH1	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
	GOT2	Aspartate aminotransferase. (430 aa)
	LOC102182773	AIRC domain-containing protein. (425 aa)
	TALDO1	Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (283 aa)
	NRARP	NOTCH regulated ankyrin repeat protein. (114 aa)
	GGH	Folate gamma-glutamyl hydrolase. (318 aa)
	PHGDH	D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (533 aa)
	CKMT1A	Uncharacterized protein; Belongs to the ATP:guanido phosphotransferase family. (416 aa)
	EGFR	Receptor protein-tyrosine kinase. (1208 aa)
	GMPS	Guanine monophosphate synthase. (693 aa)
	MTHFD2	Uncharacterized protein. (352 aa)
	SHMT2	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (502 aa)
	IDH2	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa)
	ALK	Tyrosine-protein kinase receptor. (1309 aa)
	PSPH	Phosphoserine phosphatase. (225 aa)
	ALDOC	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (493 aa)
	JAG2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1069 aa)
	HEY2	Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
	AHCY	Adenosylhomocysteinase; Belongs to the adenosylhomocysteinase family. (432 aa)
	CTPS1	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (591 aa)
	BDH1	3-hydroxybutyrate dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (344 aa)
	GCLM	Glutamate-cysteine ligase modifier subunit. (274 aa)
	UMPS	Uridine monophosphate synthetase. (507 aa)
	MDH2	Malate dehydrogenase. (338 aa)
	ACLY	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (1101 aa)
	PGAM1	Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (254 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACLY	ALDOC	ENSCHIP00000027213	ENSCHIP00000004951	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	0.418
ACLY	GAPDH	ENSCHIP00000027213	ENSCHIP00000025974	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Glyceraldehyde-3-phosphate dehydrogenase.	0.555
ACLY	GOT2	ENSCHIP00000027213	ENSCHIP00000010968	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Aspartate aminotransferase.	0.884
ACLY	IDH1	ENSCHIP00000027213	ENSCHIP00000019250	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.822
ACLY	IDH2	ENSCHIP00000027213	ENSCHIP00000001938	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.841
ACLY	MDH2	ENSCHIP00000027213	ENSCHIP00000029021	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Malate dehydrogenase.	0.976
ACLY	PC	ENSCHIP00000027213	ENSCHIP00000025566	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	0.970
ACLY	PGAM1	ENSCHIP00000027213	ENSCHIP00000026849	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.	0.433
ACLY	UMPS	ENSCHIP00000027213	ENSCHIP00000030384	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Uridine monophosphate synthetase.	0.421
AHCY	GMPS	ENSCHIP00000033026	ENSCHIP00000026603	Adenosylhomocysteinase; Belongs to the adenosylhomocysteinase family.	Guanine monophosphate synthase.	0.405
AHCY	MTHFD2	ENSCHIP00000033026	ENSCHIP00000024076	Adenosylhomocysteinase; Belongs to the adenosylhomocysteinase family.	Uncharacterized protein.	0.443
AHCY	SHMT2	ENSCHIP00000033026	ENSCHIP00000001693	Adenosylhomocysteinase; Belongs to the adenosylhomocysteinase family.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.624
ALDOC	ACLY	ENSCHIP00000004951	ENSCHIP00000027213	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	0.418
ALDOC	GAPDH	ENSCHIP00000004951	ENSCHIP00000025974	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	Glyceraldehyde-3-phosphate dehydrogenase.	0.973
ALDOC	GOT2	ENSCHIP00000004951	ENSCHIP00000010968	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	Aspartate aminotransferase.	0.411
ALDOC	IDH1	ENSCHIP00000004951	ENSCHIP00000019250	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.448
ALDOC	IDH2	ENSCHIP00000004951	ENSCHIP00000001938	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.499
ALDOC	MDH2	ENSCHIP00000004951	ENSCHIP00000029021	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	Malate dehydrogenase.	0.523
ALDOC	PGAM1	ENSCHIP00000004951	ENSCHIP00000026849	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.	0.948
ALDOC	TALDO1	ENSCHIP00000004951	ENSCHIP00000007423	Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.	Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.	0.967