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FGF2 FGF2 TMEM26 TMEM26 KL KL FABP4 FABP4 BMP7 BMP7 UCP1 UCP1 FGFR1 FGFR1 INS INS PDK1 PDK1 ACTB ACTB COX7A1 COX7A1 PPARG PPARG HOXC9 HOXC9 SHOX2 SHOX2 PRDM16 PRDM16 FGFR2 FGFR2 LOC102181743 LOC102181743 LDH-A LDH-A FASN FASN ALB ALB OTOP1 OTOP1 SLC2A4 SLC2A4 ELOVL3 ELOVL3 LIPE LIPE FGFR4 FGFR4 CIDEA CIDEA PLIN1 PLIN1 KLB KLB LOC102173997 LOC102173997 LOC106501717 LOC106501717 SLC27A1 SLC27A1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
TMEM26Transmembrane protein 26. (368 aa)
KLKlotho. (1013 aa)
FABP4Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
UCP1Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (305 aa)
FGFR1Fibroblast growth factor receptor. (860 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
PDK1Protein-serine/threonine kinase. (438 aa)
ACTBUncharacterized protein. (375 aa)
COX7A1Cytochrome c oxidase subunit 7A1. (80 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
HOXC9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (260 aa)
SHOX2Short stature homeobox 2. (319 aa)
PRDM16PR/SET domain 16. (1271 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
LOC102181743MFS domain-containing protein. (491 aa)
LDH-AL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (361 aa)
FASNFatty acid synthase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. (2755 aa)
ALBSerum albumin. (608 aa)
OTOP1Otopetrin 1. (613 aa)
SLC2A4MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
ELOVL3Elongation of very long chain fatty acids protein 3; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precurs [...] (270 aa)
LIPELipase E, hormone sensitive type. (756 aa)
FGFR4Fibroblast growth factor receptor. (870 aa)
CIDEACIDE-N domain-containing protein. (219 aa)
PLIN1Perilipin; Belongs to the perilipin family. (516 aa)
KLBKlotho beta. (1032 aa)
LOC102173997Capra hircus breed Kapro cytochrome c mRNA; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LOC106501717Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
SLC27A1Solute carrier family 27 member 1. (646 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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