39 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102171116	Uncharacterized protein. (226 aa)
	FABP4	Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
	NCOR1	Nuclear receptor corepressor 1. (2447 aa)
	PRP6	Prolactin-related protein-6. (239 aa)
	OXCT1	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (530 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
	LOC102170569	Uncharacterized protein. (211 aa)
	LOC102184390	Uncharacterized protein. (287 aa)
	LOC102190477	Uncharacterized protein. (238 aa)
	NR1H3	Uncharacterized protein. (447 aa)
	PLIN2	Perilipin; Belongs to the perilipin family. (378 aa)
	PPARD	Peroxisome proliferator activated receptor delta. (441 aa)
	FABP3	Heart-type fatty acid binding protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (133 aa)
	ACACA	Acetyl-CoA carboxylase alpha. (2329 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
	LOC102178616	Uncharacterized protein. (265 aa)
	LOC108638107	Uncharacterized protein. (238 aa)
	FASN	Fatty acid synthase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. (2755 aa)
	LPIN1	Lipin 1. (913 aa)
	SREBF2	Sterol regulatory element binding transcription factor 2. (1136 aa)
	GPAM	Glycerol-3-phosphate acyltransferase 1, mitochondrial. (844 aa)
	GPAT4	Glycerol-3-phosphate acyltransferase 4. (456 aa)
	SCD	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (By similarity). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid ox [...] (359 aa)
	VLDLR	Very low density lipoprotein receptor. (873 aa)
	UXT	Ubiquitously expressed prefoldin like chaperone. (156 aa)
	PRP1	Prolactin-related protein-1. (238 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	ACSL1	Acyl-CoA synthetase long chain family member 1. (719 aa)
	LOC102180550	Uncharacterized protein. (237 aa)
	DGAT1	O-acyltransferase. (490 aa)
	INSIG1	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (278 aa)
	RPS9	Ribosomal protein S9; Belongs to the universal ribosomal protein uS4 family. (194 aa)
	RXRA	NR LBD domain-containing protein. (106 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
	SREBF1	Uncharacterized protein. (68 aa)
	CD36	Uncharacterized protein; Belongs to the CD36 family. (472 aa)
	BDH1	3-hydroxybutyrate dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (344 aa)
	SLC27A1	Solute carrier family 27 member 1. (646 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACACA	ACSL1	ENSCHIP00000013374	ENSCHIP00000026081	Acetyl-CoA carboxylase alpha.	Acyl-CoA synthetase long chain family member 1.	0.894
ACACA	CD36	ENSCHIP00000013374	ENSCHIP00000030240	Acetyl-CoA carboxylase alpha.	Uncharacterized protein; Belongs to the CD36 family.	0.717
ACACA	DGAT1	ENSCHIP00000013374	ENSCHIP00000026908	Acetyl-CoA carboxylase alpha.	O-acyltransferase.	0.810
ACACA	FABP3	ENSCHIP00000013374	ENSCHIP00000012241	Acetyl-CoA carboxylase alpha.	Heart-type fatty acid binding protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	0.795
ACACA	FABP4	ENSCHIP00000013374	ENSCHIP00000004118	Acetyl-CoA carboxylase alpha.	Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	0.853
ACACA	FASN	ENSCHIP00000013374	ENSCHIP00000019407	Acetyl-CoA carboxylase alpha.	Fatty acid synthase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein.	0.994
ACACA	GAPDH	ENSCHIP00000013374	ENSCHIP00000025974	Acetyl-CoA carboxylase alpha.	Glyceraldehyde-3-phosphate dehydrogenase.	0.498
ACACA	GPAM	ENSCHIP00000013374	ENSCHIP00000022813	Acetyl-CoA carboxylase alpha.	Glycerol-3-phosphate acyltransferase 1, mitochondrial.	0.809
ACACA	GPAT4	ENSCHIP00000013374	ENSCHIP00000023674	Acetyl-CoA carboxylase alpha.	Glycerol-3-phosphate acyltransferase 4.	0.793
ACACA	INSIG1	ENSCHIP00000013374	ENSCHIP00000027402	Acetyl-CoA carboxylase alpha.	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	0.754
ACACA	LPIN1	ENSCHIP00000013374	ENSCHIP00000019587	Acetyl-CoA carboxylase alpha.	Lipin 1.	0.865
ACACA	NR1H3	ENSCHIP00000013374	ENSCHIP00000011675	Acetyl-CoA carboxylase alpha.	Uncharacterized protein.	0.562
ACACA	PLIN2	ENSCHIP00000013374	ENSCHIP00000011815	Acetyl-CoA carboxylase alpha.	Perilipin; Belongs to the perilipin family.	0.668
ACACA	PPARD	ENSCHIP00000013374	ENSCHIP00000011922	Acetyl-CoA carboxylase alpha.	Peroxisome proliferator activated receptor delta.	0.400
ACACA	PPARG	ENSCHIP00000013374	ENSCHIP00000015163	Acetyl-CoA carboxylase alpha.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.728
ACACA	SCD	ENSCHIP00000013374	ENSCHIP00000023844	Acetyl-CoA carboxylase alpha.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (By similarity). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid ox [...]	0.905
ACACA	SLC27A1	ENSCHIP00000013374	ENSCHIP00000033688	Acetyl-CoA carboxylase alpha.	Solute carrier family 27 member 1.	0.463
ACACA	SREBF1	ENSCHIP00000013374	ENSCHIP00000029997	Acetyl-CoA carboxylase alpha.	Uncharacterized protein.	0.906
ACACA	SREBF2	ENSCHIP00000013374	ENSCHIP00000021909	Acetyl-CoA carboxylase alpha.	Sterol regulatory element binding transcription factor 2.	0.707
ACACA	UXT	ENSCHIP00000013374	ENSCHIP00000024545	Acetyl-CoA carboxylase alpha.	Ubiquitously expressed prefoldin like chaperone.	0.430