32 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102186893	Uncharacterized protein. (709 aa)
	MUS81	MUS81 structure-specific endonuclease subunit. (552 aa)
	BRCA1	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1843 aa)
	SAMHD1	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (606 aa)
	RAD51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
	FANCA	FA complementation group A. (1416 aa)
	RAD52	RAD52 homolog, DNA repair protein. (416 aa)
	RRM2	Ribonucleotide reductase regulatory subunit M2. (389 aa)
	STAT1	Signal transducer and activator of transcription. (834 aa)
	PALB2	Partner and localizer of BRCA2. (1194 aa)
	STING1	Transmembrane protein 173. (378 aa)
	AGT	Angiotensinogen; Belongs to the serpin family. (476 aa)
	MLH1	MutL homolog 1. (758 aa)
	ACTB	Uncharacterized protein. (375 aa)
	IFIT3	Interferon induced protein with tetratricopeptide repeats 3. (492 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	STAT2	Signal transducer and activator of transcription. (851 aa)
	EMSY	EMSY transcriptional repressor, BRCA2 interacting. (1337 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3058 aa)
	IFIT2	Interferon induced protein with tetratricopeptide repeats 2. (462 aa)
	ISG15	Interferon-stimulated protein 17/ubiquitin cross-reactive protein. (157 aa)
	IFI6	Interferon alpha inducible protein 6. (135 aa)
	IRF3	Interferon regulatory factor 3. (418 aa)
	PARP1	Poly [ADP-ribose] polymerase. (1020 aa)
	CGAS	Cyclic GMP-AMP synthase. (511 aa)
	MCM2	DNA helicase; Belongs to the MCM family. (1061 aa)
	OAS1	2'-5'-oligoadenylate synthetase 1. (390 aa)
	TNFRSF1B	TNF receptor superfamily member 1B. (459 aa)
	BRCA2	BRCA2 DNA repair associated. (3405 aa)
	IFIT1	Interferon induced protein with tetratricopeptide repeats 1. (481 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	TBK1	TANK binding kinase 1. (734 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	AGT	ENSCHIP00000011080	ENSCHIP00000007185	Uncharacterized protein.	Angiotensinogen; Belongs to the serpin family.	0.426
ACTB	ATM	ENSCHIP00000011080	ENSCHIP00000016363	Uncharacterized protein.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.762
ACTB	BRCA1	ENSCHIP00000011080	ENSCHIP00000033014	Uncharacterized protein.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.750
ACTB	BRCA2	ENSCHIP00000011080	ENSCHIP00000024039	Uncharacterized protein.	BRCA2 DNA repair associated.	0.617
ACTB	CGAS	ENSCHIP00000011080	ENSCHIP00000019358	Uncharacterized protein.	Cyclic GMP-AMP synthase.	0.581
ACTB	GAPDH	ENSCHIP00000011080	ENSCHIP00000025974	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.979
ACTB	IFIT1	ENSCHIP00000011080	ENSCHIP00000024514	Uncharacterized protein.	Interferon induced protein with tetratricopeptide repeats 1.	0.623
ACTB	IFIT2	ENSCHIP00000011080	ENSCHIP00000017023	Uncharacterized protein.	Interferon induced protein with tetratricopeptide repeats 2.	0.459
ACTB	IFIT3	ENSCHIP00000011080	ENSCHIP00000012504	Uncharacterized protein.	Interferon induced protein with tetratricopeptide repeats 3.	0.463
ACTB	IRF3	ENSCHIP00000011080	ENSCHIP00000018567	Uncharacterized protein.	Interferon regulatory factor 3.	0.793
ACTB	ISG15	ENSCHIP00000011080	ENSCHIP00000017154	Uncharacterized protein.	Interferon-stimulated protein 17/ubiquitin cross-reactive protein.	0.722
ACTB	OAS1	ENSCHIP00000011080	ENSCHIP00000021642	Uncharacterized protein.	2'-5'-oligoadenylate synthetase 1.	0.504
ACTB	PARP1	ENSCHIP00000011080	ENSCHIP00000019007	Uncharacterized protein.	Poly [ADP-ribose] polymerase.	0.783
ACTB	RAD51	ENSCHIP00000011080	ENSCHIP00000033023	Uncharacterized protein.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.533
ACTB	RAD52	ENSCHIP00000011080	ENSCHIP00000004740	Uncharacterized protein.	RAD52 homolog, DNA repair protein.	0.410
ACTB	RRM2	ENSCHIP00000011080	ENSCHIP00000005712	Uncharacterized protein.	Ribonucleotide reductase regulatory subunit M2.	0.424
ACTB	STAT1	ENSCHIP00000011080	ENSCHIP00000005767	Uncharacterized protein.	Signal transducer and activator of transcription.	0.838
ACTB	STAT2	ENSCHIP00000011080	ENSCHIP00000015412	Uncharacterized protein.	Signal transducer and activator of transcription.	0.706
ACTB	TBK1	ENSCHIP00000011080	ENSCHIP00000026414	Uncharacterized protein.	TANK binding kinase 1.	0.737
AGT	ACTB	ENSCHIP00000007185	ENSCHIP00000011080	Angiotensinogen; Belongs to the serpin family.	Uncharacterized protein.	0.426