STRINGSTRING
BRD3 BRD3 CUL4A CUL4A TIPIN TIPIN LIG4 LIG4 LOC102174738 LOC102174738 RNF4 RNF4 FANCA FANCA RBBP4-2 RBBP4-2 RAD50 RAD50 VPS36 VPS36 COPS9 COPS9 SUB1 SUB1 RFC2 RFC2 CDC6 CDC6 CAND1 CAND1 TIMELESS TIMELESS COPS3 COPS3 TSSC4 TSSC4 RFC3 RFC3 RMI1 RMI1 COPS7A COPS7A CHD1L CHD1L BRD2 BRD2 INTS5 INTS5 RTEL1 RTEL1 INTS8 INTS8 RAD9A RAD9A WRNIP1 WRNIP1 WRN WRN TRAIP TRAIP FANCM FANCM RAD51C RAD51C TDP2 TDP2 SKP1 SKP1 FANCB FANCB BRD9 BRD9 PCNA PCNA TONSL TONSL RBBP4 RBBP4 GINS4 GINS4 ATM ATM ATAD5 ATAD5 RFC5 RFC5 YJU2 YJU2 PMS2 PMS2 SLX4 SLX4 INTS6 INTS6 OTX1 OTX1 POLD1 POLD1 BRD4 BRD4 DNA2 DNA2 FAAP100 FAAP100 FANCL FANCL POLE3 POLE3 TAF1 TAF1 DONSON DONSON RAD17 RAD17 RFC4 RFC4 XRCC3 XRCC3 TOP2B TOP2B POLA2 POLA2 RMI2 RMI2 FANCC FANCC GAPDH GAPDH REV3L REV3L DNMT1 DNMT1 PNKP PNKP POLE4 POLE4 POLE2 POLE2 FANCE FANCE HUS1 HUS1 ATRIP ATRIP TP53 TP53 INTS3 INTS3 CUL1 CUL1 SIRT6 SIRT6 SUMO2 SUMO2 TOPBP1 TOPBP1 BRCA1 BRCA1 COPS8 COPS8 ETAA1 ETAA1 NELFB NELFB LRR1 LRR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BRD3Bromodomain containing 3. (722 aa)
CUL4ACullin 4A; Belongs to the cullin family. (764 aa)
TIPINTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (289 aa)
LIG4DNA ligase. (911 aa)
LOC102174738Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
RNF4Ring finger protein 4. (196 aa)
FANCAFA complementation group A. (1416 aa)
RBBP4-2WD_REPEATS_REGION domain-containing protein. (425 aa)
RAD50Zinc-hook domain-containing protein. (1332 aa)
VPS36Vacuolar protein sorting 36 homolog. (457 aa)
COPS9Uncharacterized protein. (57 aa)
SUB1SUB1 regulator of transcription. (127 aa)
RFC2Replication factor C subunit 2. (352 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (562 aa)
CAND1Cullin associated and neddylation dissociated 1. (1230 aa)
TIMELESSTimeless circadian regulator. (1206 aa)
COPS3COP9 signalosome subunit 3. (423 aa)
TSSC4Tumor suppressing subtransferable candidate 4. (325 aa)
RFC3Replication factor C subunit 3. (356 aa)
RMI1RecQ mediated genome instability 1. (624 aa)
COPS7ACOP9 signalosome subunit 7A. (277 aa)
CHD1LChromodomain helicase DNA binding protein 1 like. (893 aa)
BRD2Bromodomain containing 2. (803 aa)
INTS5Integrator complex subunit 5. (1018 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1212 aa)
INTS8Integrator complex subunit 8. (1121 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (395 aa)
WRNIP1WRN helicase interacting protein 1. (640 aa)
WRNWRN RecQ like helicase. (1405 aa)
TRAIPTRAF interacting protein. (471 aa)
FANCMFA complementation group M. (2043 aa)
RAD51CRAD51 paralog C. (371 aa)
TDP2Endo/exonuclease/phosphatase domain-containing protein. (330 aa)
SKP1S-phase kinase associated protein 1. (163 aa)
FANCBUncharacterized protein. (447 aa)
BRD9Bromodomain containing 9. (577 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
TONSLTonsoku like, DNA repair protein. (1371 aa)
RBBP4WD_REPEATS_REGION domain-containing protein. (426 aa)
GINS4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3058 aa)
ATAD5ATPase family AAA domain containing 5. (1894 aa)
RFC5Replication factor C subunit 5. (339 aa)
YJU2Uncharacterized protein. (320 aa)
PMS2PMS1 homolog 2, mismatch repair system component. (887 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1752 aa)
INTS6Integrator complex subunit 6. (887 aa)
OTX1Orthodenticle homeobox 1. (355 aa)
POLD1DNA polymerase. (1115 aa)
BRD4Uncharacterized protein. (1336 aa)
DNA2DNA replication helicase/nuclease 2. (1062 aa)
FAAP100FA core complex associated protein 100. (879 aa)
FANCLRING-type domain-containing protein. (379 aa)
POLE3CBFD_NFYB_HMF domain-containing protein. (147 aa)
TAF1Transcription initiation factor TFIID subunit. (1882 aa)
DONSONDownstream neighbor of SON. (561 aa)
RAD17RAD17 checkpoint clamp loader component. (709 aa)
RFC4Replication factor C subunit 4. (364 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (341 aa)
TOP2BDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1609 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (603 aa)
RMI2Uncharacterized protein. (161 aa)
FANCCFanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (568 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
REV3LREV3 like, DNA directed polymerase zeta catalytic subunit. (3134 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1591 aa)
PNKPPolynucleotide kinase 3'-phosphatase. (522 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (131 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (518 aa)
FANCEFA complementation group E. (444 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
ATRIPATR interacting protein. (791 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
INTS3Integrator complex subunit 3. (1041 aa)
CUL1CULLIN_2 domain-containing protein; Belongs to the cullin family. (776 aa)
SIRT6Sirtuin 6. (335 aa)
SUMO2Small ubiquitin-related modifier. (95 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1521 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1843 aa)
COPS8COP9 signalosome subunit 8. (209 aa)
ETAA1ETAA1 activator of ATR kinase. (903 aa)
NELFBNegative elongation factor complex member B. (817 aa)
LRR1Leucine rich repeat protein 1. (424 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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