STRINGSTRING
CCNA2 CCNA2 LOC102191748 LOC102191748 LOC102185882 LOC102185882 LOC108633554 LOC108633554 LOC102182848 LOC102182848 PTEN PTEN LOC108636012 LOC108636012 H3-4 H3-4 LOC108634231 LOC108634231 POLD2 POLD2 LOC102180554 LOC102180554 LOC106503499 LOC106503499 LOC108633916 LOC108633916 LOC102171353 LOC102171353 LOC102169981 LOC102169981 ACTB ACTB MDC1 MDC1 E2F1 E2F1 PCNA PCNA PXDN PXDN WEE1 WEE1 MCM6 MCM6 MCM4 MCM4 POLD1 POLD1 MCM3 MCM3 XRCC1 XRCC1 POLA2 POLA2 LOC102189503 LOC102189503 ORC6 ORC6 CCNE2 CCNE2 PLK1 PLK1 POLE2 POLE2 TP53 TP53 CCND2 CCND2 CCT2 CCT2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CCNA2Cyclin A2; Belongs to the cyclin family. (430 aa)
LOC102191748Histone domain-containing protein. (136 aa)
LOC102185882Histone H3; Belongs to the histone H3 family. (136 aa)
LOC108633554Histone domain-containing protein. (136 aa)
LOC102182848Histone H3; Belongs to the histone H3 family. (136 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (402 aa)
LOC108636012Histone H3; Belongs to the histone H3 family. (136 aa)
H3-4Histone H3; Belongs to the histone H3 family. (136 aa)
LOC108634231Histone H3; Belongs to the histone H3 family. (136 aa)
POLD2DNA polymerase delta 2, accessory subunit. (469 aa)
LOC102180554Histone H3; Belongs to the histone H3 family. (136 aa)
LOC106503499Histone H3; Belongs to the histone H3 family. (136 aa)
LOC108633916Histone H3; Belongs to the histone H3 family. (136 aa)
LOC102171353Histone H3; Belongs to the histone H3 family. (136 aa)
LOC102169981Histone domain-containing protein. (136 aa)
ACTBUncharacterized protein. (375 aa)
MDC1Mediator of DNA damage checkpoint 1. (1914 aa)
E2F1E2F transcription factor 1. (441 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
PXDNPeroxidasin. (1525 aa)
WEE1Wee1-like protein kinase. (645 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
MCM4DNA helicase; Belongs to the MCM family. (851 aa)
POLD1DNA polymerase. (1115 aa)
MCM3DNA helicase; Belongs to the MCM family. (808 aa)
XRCC1X-ray repair cross complementing 1. (632 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (603 aa)
LOC102189503Histone H3; Belongs to the histone H3 family. (136 aa)
ORC6Origin recognition complex subunit 6. (252 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
PLK1Serine/threonine-protein kinase PLK. (602 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (518 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (292 aa)
CCT2Chaperonin containing TCP1 subunit 2. (535 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.