STRINGSTRING
SPARCL1 SPARCL1 CSF1 CSF1 CCND3 CCND3 COL15A1 COL15A1 CEBPB CEBPB COL5A3 COL5A3 COL1A2 COL1A2 PDGFRB PDGFRB SMOC2 SMOC2 LOC102182683 LOC102182683 PLIN1 PLIN1 COL8A2 COL8A2 PLIN3 PLIN3 ITGA7 ITGA7 PAX7 PAX7 KCNJ8 KCNJ8 FGFR4 FGFR4 CCNE2 CCNE2 COL14A1 COL14A1 CSPG4 CSPG4 KIT KIT COL4A1 COL4A1 MKX MKX LOC102174895 LOC102174895 COL1A1 COL1A1 DPP4 DPP4 NID1 NID1 PLIN5 PLIN5 LAMA4 LAMA4 COL12A1 COL12A1 NID2 NID2 COL6A3 COL6A3 FGF2 FGF2 FBLN1 FBLN1 COL6A2 COL6A2 ACTA2 ACTA2 MGP MGP CCNA2 CCNA2 FBLN5 FBLN5 SEMA3C SEMA3C NOTCH3 NOTCH3 LOX LOX SCX SCX COL8A1 COL8A1 CCNB1 CCNB1 PODN PODN HIC1 HIC1 SDC3 SDC3 MYF5 MYF5 TAGLN TAGLN LAMC1 LAMC1 PLIN2 PLIN2 CXCR4 CXCR4 BIRC5 BIRC5 COL5A2 COL5A2 IGFBP5 IGFBP5 CEBPA CEBPA ADAM12 ADAM12 LAMA2 LAMA2 CCND1 CCND1 CXCL5 CXCL5 CEBPD CEBPD TCF7L2 TCF7L2 CXCL14 CXCL14 SFRP4 SFRP4 POSTN POSTN TBP TBP GLI1 GLI1 BGN BGN CD34 CD34 PDGFRA PDGFRA TNMD TNMD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SPARCL1SPARC like 1. (653 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (554 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (292 aa)
COL15A1Collagen type XV alpha 1 chain. (1375 aa)
CEBPBCCAAT/enhancer-binding protein. (307 aa)
COL5A3Collagen type V alpha 3 chain. (1455 aa)
COL1A2Collagen type I alpha 2 chain. (1128 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
SMOC2SPARC related modular calcium binding 2. (445 aa)
LOC102182683C-X-C motif chemokine. (109 aa)
PLIN1Perilipin; Belongs to the perilipin family. (516 aa)
COL8A2Collagen type VIII alpha 2 chain. (704 aa)
PLIN3Perilipin; Belongs to the perilipin family. (438 aa)
ITGA7Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1181 aa)
PAX7Paired box 7. (503 aa)
KCNJ8Potassium voltage-gated channel subfamily J member 8. (424 aa)
FGFR4Fibroblast growth factor receptor. (870 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
COL14A1Collagen type XIV alpha 1 chain. (1775 aa)
CSPG4Chondroitin sulfate proteoglycan 4. (2340 aa)
KITMast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (974 aa)
COL4A1Collagen type IV alpha 1 chain. (1608 aa)
MKXMohawk homeobox. (352 aa)
LOC102174895Uncharacterized protein. (735 aa)
COL1A1Collagen type I alpha 1 chain. (1463 aa)
DPP4Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. (767 aa)
NID1Nidogen 1. (1252 aa)
PLIN5Perilipin; Belongs to the perilipin family. (456 aa)
LAMA4Laminin subunit alpha 4. (1824 aa)
COL12A1Collagen type XII alpha 1 chain. (3046 aa)
NID2Nidogen 2. (1305 aa)
COL6A3Collagen type VI alpha 3 chain. (3111 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (713 aa)
COL6A2Collagen type VI alpha 2 chain. (1027 aa)
ACTA2Actin alpha 2, smooth muscle. (377 aa)
MGPMatrix Gla protein; Associates with the organic matrix of bone and cartilage. (101 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (430 aa)
FBLN5Fibulin 5. (448 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (765 aa)
NOTCH3Notch receptor 3. (2332 aa)
LOXLysyl oxidase. (418 aa)
SCXScleraxis bHLH transcription factor. (201 aa)
COL8A1Collagen type VIII alpha 1 chain. (745 aa)
CCNB1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (427 aa)
PODNPodocan. (614 aa)
HIC1HIC ZBTB transcriptional repressor 1. (733 aa)
SDC3Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (442 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (260 aa)
TAGLNTransgelin; Belongs to the calponin family. (201 aa)
LAMC1Laminin subunit gamma 1. (1608 aa)
PLIN2Perilipin; Belongs to the perilipin family. (378 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (353 aa)
BIRC5Uncharacterized protein. (142 aa)
COL5A2Collagen type V alpha 2 chain. (1252 aa)
IGFBP5Insulin-like growth factor binding protein 5. (272 aa)
CEBPACCAAT enhancer binding protein alpha. (353 aa)
ADAM12ADAM metallopeptidase domain 12. (903 aa)
LAMA2Laminin subunit alpha 2. (3116 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
CXCL5C-X-C motif chemokine. (119 aa)
CEBPDCCAAT/enhancer-binding protein. (256 aa)
TCF7L2Transcription factor 7 like 2. (669 aa)
CXCL14C-X-C motif chemokine ligand 14. (99 aa)
SFRP4Secreted frizzled related protein 4. (346 aa)
POSTNPeriostin. (836 aa)
TBPUncharacterized protein. (327 aa)
GLI1GLI family zinc finger 1. (1105 aa)
BGNBiglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (373 aa)
CD34Uncharacterized protein. (384 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1108 aa)
TNMDTenomodulin. (318 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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