STRINGSTRING
TP53 TP53 THY1 THY1 EDN2 EDN2 LUM LUM MMP3 MMP3 NFIX NFIX COL4A1 COL4A1 POSTN POSTN SIRT1 SIRT1 INS INS CWH43 CWH43 NFIA NFIA BIRC5 BIRC5 NFIC NFIC PPARG PPARG RUNX2 RUNX2 PXDN PXDN UBE2C UBE2C SBSN SBSN TK1 TK1 FBLN5 FBLN5 COL6A2 COL6A2 DCN DCN AEBP1 AEBP1 SPINK6 SPINK6 HJURP HJURP NID1 NID1 COL1A1 COL1A1 KLK12 KLK12 SP7 SP7 ADAMTS4 ADAMTS4 KRT4 KRT4 FMOD FMOD COL4A2 COL4A2 COL5A3 COL5A3 COL1A2 COL1A2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
THY1Thy-1 cell surface antigen. (161 aa)
EDN2Endothelin 2. (177 aa)
LUMLumican. (342 aa)
MMP3Matrix metallopeptidase 3. (477 aa)
NFIXNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (503 aa)
COL4A1Collagen type IV alpha 1 chain. (1608 aa)
POSTNPeriostin. (836 aa)
SIRT1Deacetylase sirtuin-type domain-containing protein. (732 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
CWH43Cell wall biogenesis 43 C-terminal homolog. (690 aa)
NFIANuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (509 aa)
BIRC5Uncharacterized protein. (142 aa)
NFICNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (506 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
RUNX2RUNX family transcription factor 2. (585 aa)
PXDNPeroxidasin. (1525 aa)
UBE2CUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (172 aa)
SBSNSuprabasin. (575 aa)
TK1Thymidine kinase. (238 aa)
FBLN5Fibulin 5. (448 aa)
COL6A2Collagen type VI alpha 2 chain. (1027 aa)
DCNDecorin; May affect the rate of fibrils formation. (360 aa)
AEBP1AE binding protein 1. (1161 aa)
SPINK6Serine peptidase inhibitor, Kazal type 6. (105 aa)
HJURPHolliday junction recognition protein. (694 aa)
NID1Nidogen 1. (1252 aa)
COL1A1Collagen type I alpha 1 chain. (1463 aa)
KLK12Kallikrein related peptidase 12; Belongs to the peptidase S1 family. (248 aa)
SP7Sp7 transcription factor. (431 aa)
ADAMTS4ADAM metallopeptidase with thrombospondin type 1 motif 4. (872 aa)
KRT4Keratin 4; Belongs to the intermediate filament family. (555 aa)
FMODFibromodulin. (376 aa)
COL4A2Collagen type IV alpha 2 chain. (1607 aa)
COL5A3Collagen type V alpha 3 chain. (1455 aa)
COL1A2Collagen type I alpha 2 chain. (1128 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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