32 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	COL4A1	Collagen type IV alpha 1 chain. (1608 aa)
	MMP15	Matrix metallopeptidase 15. (675 aa)
	FGF14	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (247 aa)
	BGN	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (373 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (230 aa)
	POSTN	Periostin. (836 aa)
	TRIL	TLR4 interactor with leucine rich repeats. (810 aa)
	BMP7	Bone morphogenetic protein 7. (431 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	IL6R	Interleukin 6 receptor. (441 aa)
	COL5A2	Collagen type V alpha 2 chain. (1252 aa)
	MMP16	Matrix metallopeptidase 16. (607 aa)
	ACTB	Uncharacterized protein. (375 aa)
	MMP25	Matrix metallopeptidase 25. (593 aa)
	LOXL2	Lysyl oxidase like 2. (791 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	TCF21	Transcription factor 21. (179 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
	COL8A1	Collagen type VIII alpha 1 chain. (745 aa)
	COL6A2	Collagen type VI alpha 2 chain. (1027 aa)
	LTB	Lymphotoxin beta; Belongs to the tumor necrosis factor family. (301 aa)
	ADAMTS5	ADAM metallopeptidase with thrombospondin type 1 motif 5. (934 aa)
	SERPINE1	Serpin family E member 1; Belongs to the serpin family. (402 aa)
	COL1A1	Collagen type I alpha 1 chain. (1463 aa)
	FBN1	Fibrillin 1. (2860 aa)
	APOE	Apolipoprotein E. (326 aa)
	HBEGF	Heparin binding EGF like growth factor. (208 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
	MMP23B	Matrix metallopeptidase 23B. (393 aa)
	COL1A2	Collagen type I alpha 2 chain. (1128 aa)
	BMP10	Bone morphogenetic protein 10. (424 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ADAMTS5	ENSCHIP00000011080	ENSCHIP00000020287	Uncharacterized protein.	ADAM metallopeptidase with thrombospondin type 1 motif 5.	0.548
ACTB	APOE	ENSCHIP00000011080	ENSCHIP00000025098	Uncharacterized protein.	Apolipoprotein E.	0.753
ACTB	BGN	ENSCHIP00000011080	ENSCHIP00000003173	Uncharacterized protein.	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	0.436
ACTB	BMP7	ENSCHIP00000011080	ENSCHIP00000006043	Uncharacterized protein.	Bone morphogenetic protein 7.	0.547
ACTB	COL1A1	ENSCHIP00000011080	ENSCHIP00000023918	Uncharacterized protein.	Collagen type I alpha 1 chain.	0.776
ACTB	COL1A2	ENSCHIP00000011080	ENSCHIP00000031191	Uncharacterized protein.	Collagen type I alpha 2 chain.	0.563
ACTB	FGF7	ENSCHIP00000011080	ENSCHIP00000014609	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.593
ACTB	HBEGF	ENSCHIP00000011080	ENSCHIP00000026288	Uncharacterized protein.	Heparin binding EGF like growth factor.	0.431
ACTB	IL1B	ENSCHIP00000011080	ENSCHIP00000029274	Uncharacterized protein.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.918
ACTB	IL6R	ENSCHIP00000011080	ENSCHIP00000009581	Uncharacterized protein.	Interleukin 6 receptor.	0.495
ACTB	INS	ENSCHIP00000011080	ENSCHIP00000007610	Uncharacterized protein.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.884
ACTB	POSTN	ENSCHIP00000011080	ENSCHIP00000004170	Uncharacterized protein.	Periostin.	0.515
ACTB	SERPINE1	ENSCHIP00000011080	ENSCHIP00000023172	Uncharacterized protein.	Serpin family E member 1; Belongs to the serpin family.	0.634
ACTB	TGFB1	ENSCHIP00000011080	ENSCHIP00000008885	Uncharacterized protein.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.831
ACTB	TREM2	ENSCHIP00000011080	ENSCHIP00000003876	Uncharacterized protein.	Triggering receptor expressed on myeloid cells 2.	0.454
ACTB	WNT5A	ENSCHIP00000011080	ENSCHIP00000015533	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.615
ADAMTS5	ACTB	ENSCHIP00000020287	ENSCHIP00000011080	ADAM metallopeptidase with thrombospondin type 1 motif 5.	Uncharacterized protein.	0.548
ADAMTS5	BGN	ENSCHIP00000020287	ENSCHIP00000003173	ADAM metallopeptidase with thrombospondin type 1 motif 5.	Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	0.494
ADAMTS5	COL1A1	ENSCHIP00000020287	ENSCHIP00000023918	ADAM metallopeptidase with thrombospondin type 1 motif 5.	Collagen type I alpha 1 chain.	0.553
ADAMTS5	IL1B	ENSCHIP00000020287	ENSCHIP00000029274	ADAM metallopeptidase with thrombospondin type 1 motif 5.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.793