STRINGSTRING
GFAP GFAP LOC102182683 LOC102182683 NUBP2 NUBP2 CCN2 CCN2 ITGA11 ITGA11 COL1A2 COL1A2 LAMB1 LAMB1 COL4A2 COL4A2 COL14A1 COL14A1 TGFB2 TGFB2 COL4A1 COL4A1 TLN2 TLN2 COL1A1 COL1A1 ITGA1 ITGA1 MMP13 MMP13 NID1 NID1 EGFR EGFR LAMA4 LAMA4 ALB ALB NID2 NID2 COL6A6 COL6A6 FGF2 FGF2 COL6A2 COL6A2 LRAT LRAT COL8A1 COL8A1 RELN RELN PPARG PPARG ITGA5 ITGA5 CXCR4 CXCR4 ITGA6 ITGA6 COL5A2 COL5A2 IL6 IL6 TGFB1 TGFB1 IL1A IL1A LAMA2 LAMA2 INS INS LAMA5 LAMA5 CXCL12 CXCL12 ITGB1 ITGB1 COL6A5 COL6A5 TIMP1 TIMP1 HGF HGF FABP4 FABP4 NGF NGF SPARCL1 SPARCL1 TGFB3 TGFB3 COL4A5 COL4A5 VCL VCL NES NES CSF2 CSF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (428 aa)
LOC102182683C-X-C motif chemokine. (109 aa)
NUBP2Cytosolic Fe-S cluster assembly factor NUBP2; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily. (273 aa)
CCN2Cellular communication network factor 2. (349 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1209 aa)
COL1A2Collagen type I alpha 2 chain. (1128 aa)
LAMB1Laminin subunit beta 1. (1842 aa)
COL4A2Collagen type IV alpha 2 chain. (1607 aa)
COL14A1Collagen type XIV alpha 1 chain. (1775 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
COL4A1Collagen type IV alpha 1 chain. (1608 aa)
TLN2Talin 2. (2542 aa)
COL1A1Collagen type I alpha 1 chain. (1463 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1179 aa)
MMP13Matrix metallopeptidase 13. (472 aa)
NID1Nidogen 1. (1252 aa)
EGFRReceptor protein-tyrosine kinase. (1208 aa)
LAMA4Laminin subunit alpha 4. (1824 aa)
ALBSerum albumin. (608 aa)
NID2Nidogen 2. (1305 aa)
COL6A6Collagen type VI alpha 6 chain. (2265 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
COL6A2Collagen type VI alpha 2 chain. (1027 aa)
LRATLecithin retinol acyltransferase. (230 aa)
COL8A1Collagen type VIII alpha 1 chain. (745 aa)
RELNReelin. (3469 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1100 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (353 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1072 aa)
COL5A2Collagen type V alpha 2 chain. (1252 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (254 aa)
LAMA2Laminin subunit alpha 2. (3116 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
LAMA5Laminin subunit alpha 5. (2263 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (116 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
COL6A5Collagen type VI alpha 5 chain. (2241 aa)
TIMP1NTR domain-containing protein. (207 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (814 aa)
FABP4Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (241 aa)
SPARCL1SPARC like 1. (653 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
COL4A5Collagen IV NC1 domain-containing protein. (568 aa)
VCLVinculin. (1134 aa)
NESNestin; Belongs to the intermediate filament family. (1606 aa)
CSF2Granulocyte-macrophage colony stimulating factor. (144 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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