STRINGSTRING
TP53 TP53 GAPDH GAPDH MTOR MTOR SLC35B2 SLC35B2 B4GALT7 B4GALT7 TADA2B TADA2B B3GAT3 B3GAT3 SIN3B SIN3B HIF1A HIF1A DOT1L DOT1L C9orf72 C9orf72 AMOTL2 AMOTL2 TAF6L TAF6L CASP3 CASP3 CDKN1A CDKN1A MED16 MED16 SMCHD1 SMCHD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
SLC35B2Solute carrier family 35 member B2. (437 aa)
B4GALT7Beta-1,4-galactosyltransferase 7. (327 aa)
TADA2BTranscriptional adapter. (420 aa)
B3GAT3Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family. (335 aa)
SIN3BSIN3 transcription regulator family member B. (1142 aa)
HIF1AUncharacterized protein. (823 aa)
DOT1LHistone-lysine N-methyltransferase, H3 lysine-79 specific. (1713 aa)
C9orf72C9orf72-SMCR8 complex subunit. (481 aa)
AMOTL2Angiomotin like 2. (767 aa)
TAF6LTATA-box binding protein associated factor 6 like. (619 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (275 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (161 aa)
MED16Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (847 aa)
SMCHD1Structural maintenance of chromosomes flexible hinge domain containing 1. (1987 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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