31 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FASN	Fatty acid synthase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. (2755 aa)
	COL6A3	Collagen type VI alpha 3 chain. (3111 aa)
	IL10	Interleukin 10. (177 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
	COL8A1	Collagen type VIII alpha 1 chain. (745 aa)
	NRP2	Neuropilin; Belongs to the neuropilin family. (926 aa)
	LIPG	Lipase G, endothelial type. (563 aa)
	CISH	Cytokine inducible SH2 containing protein. (254 aa)
	ACTB	Uncharacterized protein. (375 aa)
	COL18A1	Endostatin domain-containing protein. (189 aa)
	UNC5B	Unc-5 netrin receptor B. (945 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
	RPSA	40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteri [...] (294 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	CD4	CD4 molecule. (455 aa)
	SOD2	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
	TANC2	Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2. (1990 aa)
	CSF2	Granulocyte-macrophage colony stimulating factor. (144 aa)
	ARHGAP31	Rho GTPase activating protein 31. (1450 aa)
	MMP12	Matrix metallopeptidase 12. (470 aa)
	BCL6	BCL6 transcription repressor. (706 aa)
	COL4A2	Collagen type IV alpha 2 chain. (1607 aa)
	NFE2L2	Nuclear factor erythroid 2-related factor 2. (616 aa)
	COL1A2	Collagen type I alpha 2 chain. (1128 aa)
	MET	MET proto-oncogene, receptor tyrosine kinase. (1384 aa)
	ITSN1	Intersectin 1. (1716 aa)
	COL4A1	Collagen type IV alpha 1 chain. (1608 aa)
	ARG1	Arginase. (322 aa)
	COL1A1	Collagen type I alpha 1 chain. (1463 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)
	SLCO2A1	Solute carrier organic anion transporter family member. (658 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ARG1	ENSCHIP00000011080	ENSCHIP00000025258	Uncharacterized protein.	Arginase.	0.769
ACTB	BCL6	ENSCHIP00000011080	ENSCHIP00000032540	Uncharacterized protein.	BCL6 transcription repressor.	0.600
ACTB	CD4	ENSCHIP00000011080	ENSCHIP00000006662	Uncharacterized protein.	CD4 molecule.	0.883
ACTB	COL1A1	ENSCHIP00000011080	ENSCHIP00000023918	Uncharacterized protein.	Collagen type I alpha 1 chain.	0.776
ACTB	COL1A2	ENSCHIP00000011080	ENSCHIP00000031191	Uncharacterized protein.	Collagen type I alpha 2 chain.	0.563
ACTB	CSF2	ENSCHIP00000011080	ENSCHIP00000033907	Uncharacterized protein.	Granulocyte-macrophage colony stimulating factor.	0.769
ACTB	FASN	ENSCHIP00000011080	ENSCHIP00000019407	Uncharacterized protein.	Fatty acid synthase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein.	0.723
ACTB	IFNG	ENSCHIP00000011080	ENSCHIP00000016152	Uncharacterized protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family.	0.875
ACTB	IL10	ENSCHIP00000011080	ENSCHIP00000016929	Uncharacterized protein.	Interleukin 10.	0.865
ACTB	IL6	ENSCHIP00000011080	ENSCHIP00000009414	Uncharacterized protein.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.919
ACTB	ITSN1	ENSCHIP00000011080	ENSCHIP00000026127	Uncharacterized protein.	Intersectin 1.	0.546
ACTB	MMP12	ENSCHIP00000011080	ENSCHIP00000032834	Uncharacterized protein.	Matrix metallopeptidase 12.	0.441
ACTB	NFE2L2	ENSCHIP00000011080	ENSCHIP00000031851	Uncharacterized protein.	Nuclear factor erythroid 2-related factor 2.	0.716
ACTB	RPSA	ENSCHIP00000011080	ENSCHIP00000008913	Uncharacterized protein.	40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteri [...]	0.493
ACTB	SOD2	ENSCHIP00000011080	ENSCHIP00000006131	Uncharacterized protein.	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.	0.770
ACTB	STAT3	ENSCHIP00000011080	ENSCHIP00000022282	Uncharacterized protein.	Signal transducer and activator of transcription.	0.882
ACTB	TGFB1	ENSCHIP00000011080	ENSCHIP00000008885	Uncharacterized protein.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.831
ARG1	ACTB	ENSCHIP00000025258	ENSCHIP00000011080	Arginase.	Uncharacterized protein.	0.769
ARG1	CD4	ENSCHIP00000025258	ENSCHIP00000006662	Arginase.	CD4 molecule.	0.914
ARG1	CSF2	ENSCHIP00000025258	ENSCHIP00000033907	Arginase.	Granulocyte-macrophage colony stimulating factor.	0.695