21 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	MAP2	Microtubule-associated protein. (1868 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
	ADAM12	ADAM metallopeptidase domain 12. (903 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (452 aa)
	TNFRSF1A	TNF receptor superfamily member 1A. (449 aa)
	ACTB	Uncharacterized protein. (375 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (275 aa)
	MAP4	Microtubule-associated protein. (1106 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	PXDN	Peroxidasin. (1525 aa)
	BCL2	BH4_2 domain-containing protein. (229 aa)
	BAX	BCL2 associated X, apoptosis regulator. (192 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
	ALB	Serum albumin. (608 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
	ATG12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
	MAPT	Microtubule-associated protein. (744 aa)
	ATG16L1	Autophagy related 16 like 1. (607 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ALB	ENSCHIP00000011080	ENSCHIP00000020234	Uncharacterized protein.	Serum albumin.	0.961
ACTB	ATG12	ENSCHIP00000011080	ENSCHIP00000029307	Uncharacterized protein.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.731
ACTB	ATG16L1	ENSCHIP00000011080	ENSCHIP00000032565	Uncharacterized protein.	Autophagy related 16 like 1.	0.574
ACTB	ATG5	ENSCHIP00000011080	ENSCHIP00000021333	Uncharacterized protein.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.863
ACTB	BCL2	ENSCHIP00000011080	ENSCHIP00000015831	Uncharacterized protein.	BH4_2 domain-containing protein.	0.940
ACTB	CASP3	ENSCHIP00000011080	ENSCHIP00000011490	Uncharacterized protein.	Caspase 3; Belongs to the peptidase C14A family.	0.996
ACTB	CASP9	ENSCHIP00000011080	ENSCHIP00000008590	Uncharacterized protein.	Caspase 9; Belongs to the peptidase C14A family.	0.891
ACTB	IFNG	ENSCHIP00000011080	ENSCHIP00000016152	Uncharacterized protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family.	0.875
ACTB	IL1B	ENSCHIP00000011080	ENSCHIP00000029274	Uncharacterized protein.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.918
ACTB	MAP2	ENSCHIP00000011080	ENSCHIP00000000751	Uncharacterized protein.	Microtubule-associated protein.	0.724
ACTB	MAPT	ENSCHIP00000011080	ENSCHIP00000032228	Uncharacterized protein.	Microtubule-associated protein.	0.563
ACTB	MTOR	ENSCHIP00000011080	ENSCHIP00000021872	Uncharacterized protein.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.734
ACTB	PXDN	ENSCHIP00000011080	ENSCHIP00000015493	Uncharacterized protein.	Peroxidasin.	0.962
ACTB	TNF	ENSCHIP00000011080	ENSCHIP00000004561	Uncharacterized protein.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.886
ACTB	TNFRSF1A	ENSCHIP00000011080	ENSCHIP00000010109	Uncharacterized protein.	TNF receptor superfamily member 1A.	0.451
ACTB	TP53	ENSCHIP00000011080	ENSCHIP00000030141	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.907
ALB	ACTB	ENSCHIP00000020234	ENSCHIP00000011080	Serum albumin.	Uncharacterized protein.	0.961
ALB	ATG12	ENSCHIP00000020234	ENSCHIP00000029307	Serum albumin.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.525
ALB	ATG5	ENSCHIP00000020234	ENSCHIP00000021333	Serum albumin.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.700
ALB	BCL2	ENSCHIP00000020234	ENSCHIP00000015831	Serum albumin.	BH4_2 domain-containing protein.	0.866