40 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CDK6	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
	POLR2B	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1174 aa)
	CCND1	Cyclin D1; Belongs to the cyclin family. (295 aa)
	PSMA5	Proteasome subunit alpha type. (241 aa)
	CDK1	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (312 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa)
	PSMD14	MPN domain-containing protein. (310 aa)
	POLR2D	RNA polymerase II subunit D. (142 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1250 aa)
	STK33	Serine/threonine kinase 33; Belongs to the protein kinase superfamily. (473 aa)
	CCT2	Chaperonin containing TCP1 subunit 2. (535 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
	POLR2G	RNA polymerase II subunit G. (189 aa)
	RPA3	Uncharacterized protein. (121 aa)
	BRCA1	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1843 aa)
	NOP56	NOP56 ribonucleoprotein. (596 aa)
	PSMB6	Proteasome subunit beta. (239 aa)
	MAP2K7	Mitogen-activated protein kinase kinase 7. (558 aa)
	BRCA2	BRCA2 DNA repair associated. (3405 aa)
	EGFR	Receptor protein-tyrosine kinase. (1208 aa)
	RASSF5	Ras association domain family member 5. (420 aa)
	ARID1B	AT-rich interaction domain 1B. (1539 aa)
	RALB	RAS like proto-oncogene B. (206 aa)
	RHO	Rhodopsin. (348 aa)
	RPA2	Replication protein A2. (270 aa)
	PAK2	Non-specific serine/threonine protein kinase. (524 aa)
	CCT8	Chaperonin containing TCP1 subunit 8. (553 aa)
	WEE1	Wee1-like protein kinase. (645 aa)
	YAP1	Yes associated protein 1. (503 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	GATA2	GATA binding protein 2. (480 aa)
	DNMT3A	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (915 aa)
	CCT4	T-complex protein 1 subunit delta. (541 aa)
	RHOA	Ras-like protein family member A. (193 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
	ACTB	Uncharacterized protein. (375 aa)
	PSMA2	Proteasome subunit alpha type. (234 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ARID1B	ENSCHIP00000011080	ENSCHIP00000022044	Uncharacterized protein.	AT-rich interaction domain 1B.	0.857
ACTB	BRCA1	ENSCHIP00000011080	ENSCHIP00000033014	Uncharacterized protein.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.750
ACTB	BRCA2	ENSCHIP00000011080	ENSCHIP00000024039	Uncharacterized protein.	BRCA2 DNA repair associated.	0.617
ACTB	CCND1	ENSCHIP00000011080	ENSCHIP00000006815	Uncharacterized protein.	Cyclin D1; Belongs to the cyclin family.	0.890
ACTB	CCT2	ENSCHIP00000011080	ENSCHIP00000031404	Uncharacterized protein.	Chaperonin containing TCP1 subunit 2.	0.452
ACTB	CDK1	ENSCHIP00000011080	ENSCHIP00000000505	Uncharacterized protein.	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.	0.790
ACTB	CDK6	ENSCHIP00000011080	ENSCHIP00000008415	Uncharacterized protein.	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	0.793
ACTB	DNMT3A	ENSCHIP00000011080	ENSCHIP00000012630	Uncharacterized protein.	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.729
ACTB	EGFR	ENSCHIP00000011080	ENSCHIP00000022759	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.891
ACTB	ERBB2	ENSCHIP00000011080	ENSCHIP00000031717	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.755
ACTB	GRB2	ENSCHIP00000011080	ENSCHIP00000015407	Uncharacterized protein.	Growth factor receptor bound protein 2.	0.762
ACTB	HRAS	ENSCHIP00000011080	ENSCHIP00000002180	Uncharacterized protein.	HRas proto-oncogene, GTPase.	0.682
ACTB	INS	ENSCHIP00000011080	ENSCHIP00000007610	Uncharacterized protein.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.884
ACTB	KRAS	ENSCHIP00000011080	ENSCHIP00000032733	Uncharacterized protein.	KRAS proto-oncogene, GTPase.	0.795
ACTB	MYC	ENSCHIP00000011080	ENSCHIP00000011576	Uncharacterized protein.	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.716
ACTB	RHO	ENSCHIP00000011080	ENSCHIP00000020505	Uncharacterized protein.	Rhodopsin.	0.665
ACTB	RHOA	ENSCHIP00000011080	ENSCHIP00000011951	Uncharacterized protein.	Ras-like protein family member A.	0.986
ACTB	TP53	ENSCHIP00000011080	ENSCHIP00000030141	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.907
ACTB	WEE1	ENSCHIP00000011080	ENSCHIP00000017229	Uncharacterized protein.	Wee1-like protein kinase.	0.528
ACTB	YAP1	ENSCHIP00000011080	ENSCHIP00000017099	Uncharacterized protein.	Yes associated protein 1.	0.642