STRINGSTRING
CDK2 CDK2 CDK1 CDK1 FEN1 FEN1 CCND1 CCND1 MCM5 MCM5 PCNA PCNA MCM4 MCM4 DNA2 DNA2 CDK3 CDK3 MCM3 MCM3 CDK4 CDK4 GAPDH GAPDH CDK7 CDK7 CDK5 CDK5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDK2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (346 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (312 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
MCM4DNA helicase; Belongs to the MCM family. (851 aa)
DNA2DNA replication helicase/nuclease 2. (1062 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa)
MCM3DNA helicase; Belongs to the MCM family. (808 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
CDK7Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (347 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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