(25 nodes) (2020) R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling. network (Capra hircus)

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	RNF146	Uncharacterized protein. (352 aa)
	RSPO2	R-spondin 2. (243 aa)
	AXIN2	Axin 2. (844 aa)
	GPC4	Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (556 aa)
	FURIN	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (794 aa)
	DPM3	Dolichol-phosphate mannosyltransferase subunit 3; Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER. Belongs to the DPM3 family. (92 aa)
	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P; Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. (128 aa)
	FZD5	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
	AXIN1	Axin 1. (867 aa)
	PIGL	Phosphatidylinositol glycan anchor biosynthesis class L. (253 aa)
	ZNRF3	Zinc and ring finger 3. (941 aa)
	RNF43	RING-type domain-containing protein. (813 aa)
	LRP6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
	DOT1L	Histone-lysine N-methyltransferase, H3 lysine-79 specific. (1713 aa)
	RSPO4	R-spondin 4. (232 aa)
	SDC3	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (442 aa)
	PXDN	Peroxidasin. (1525 aa)
	CREBBP	CREB binding protein. (2435 aa)
	GPC3	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (509 aa)
	SDC1	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (312 aa)
	CD276	CD276 molecule. (533 aa)
	GPC1	Glypican 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (559 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	LGR4	Leucine rich repeat containing G protein-coupled receptor 4. (951 aa)
	EXTL3	Exostosin like glycosyltransferase 3; Belongs to the glycosyltransferase 47 family. (919 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AXIN1	AXIN2	ENSCHIP00000006499	ENSCHIP00000022676	Axin 1.	Axin 2.	0.984
AXIN1	CTNNB1	ENSCHIP00000006499	ENSCHIP00000031016	Axin 1.	Catenin beta 1.	0.999
AXIN1	FZD5	ENSCHIP00000006499	ENSCHIP00000003369	Axin 1.	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family.	0.599
AXIN1	LRP6	ENSCHIP00000006499	ENSCHIP00000013402	Axin 1.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.989
AXIN1	RNF146	ENSCHIP00000006499	ENSCHIP00000026134	Axin 1.	Uncharacterized protein.	0.771
AXIN1	RNF43	ENSCHIP00000006499	ENSCHIP00000008635	Axin 1.	RING-type domain-containing protein.	0.440
AXIN2	AXIN1	ENSCHIP00000022676	ENSCHIP00000006499	Axin 2.	Axin 1.	0.984
AXIN2	CTNNB1	ENSCHIP00000022676	ENSCHIP00000031016	Axin 2.	Catenin beta 1.	0.998
AXIN2	FZD5	ENSCHIP00000022676	ENSCHIP00000003369	Axin 2.	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family.	0.719
AXIN2	LGR4	ENSCHIP00000022676	ENSCHIP00000033821	Axin 2.	Leucine rich repeat containing G protein-coupled receptor 4.	0.606
AXIN2	LRP6	ENSCHIP00000022676	ENSCHIP00000013402	Axin 2.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.953
AXIN2	PXDN	ENSCHIP00000022676	ENSCHIP00000015493	Axin 2.	Peroxidasin.	0.451
AXIN2	RNF146	ENSCHIP00000022676	ENSCHIP00000026134	Axin 2.	Uncharacterized protein.	0.774
AXIN2	RNF43	ENSCHIP00000022676	ENSCHIP00000008635	Axin 2.	RING-type domain-containing protein.	0.743
AXIN2	RSPO2	ENSCHIP00000022676	ENSCHIP00000022352	Axin 2.	R-spondin 2.	0.588
AXIN2	RSPO4	ENSCHIP00000022676	ENSCHIP00000014527	Axin 2.	R-spondin 4.	0.418
AXIN2	ZNRF3	ENSCHIP00000022676	ENSCHIP00000008055	Axin 2.	Zinc and ring finger 3.	0.713
CREBBP	CTNNB1	ENSCHIP00000018072	ENSCHIP00000031016	CREB binding protein.	Catenin beta 1.	0.999
CREBBP	PXDN	ENSCHIP00000018072	ENSCHIP00000015493	CREB binding protein.	Peroxidasin.	0.453
CTNNB1	AXIN1	ENSCHIP00000031016	ENSCHIP00000006499	Catenin beta 1.	Axin 1.	0.999