STRINGSTRING
MMP8 MMP8 CD8A CD8A MMP12 MMP12 NECTIN1 NECTIN1 COL4A2 COL4A2 COL1A2 COL1A2 IL1B IL1B NUBP2 NUBP2 COL14A1 COL14A1 BTLA BTLA TIMP3 TIMP3 IL17A IL17A COL4A1 COL4A1 DUSP1 DUSP1 COL1A1 COL1A1 IL13 IL13 LDLR LDLR SMAD7 SMAD7 LOC102190507 LOC102190507 KLF4 KLF4 MMP9 MMP9 IL10 IL10 IFNG IFNG ACE2 ACE2 ICAM1 ICAM1 COL17A1 COL17A1 ACTB ACTB CCL11 CCL11 IL6 IL6 TGFB1 TGFB1 IL1A IL1A NFKBIA NFKBIA STAT1 STAT1 SKIL SKIL TLR5 TLR5 IL5 IL5 CSF2 CSF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MMP8Matrix metallopeptidase 8. (470 aa)
CD8ACD8a molecule. (233 aa)
MMP12Matrix metallopeptidase 12. (470 aa)
NECTIN1Nectin cell adhesion molecule 1. (515 aa)
COL4A2Collagen type IV alpha 2 chain. (1607 aa)
COL1A2Collagen type I alpha 2 chain. (1128 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
NUBP2Cytosolic Fe-S cluster assembly factor NUBP2; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily. (273 aa)
COL14A1Collagen type XIV alpha 1 chain. (1775 aa)
BTLAB and T lymphocyte associated. (303 aa)
TIMP3Tissue inhibitor of metalloproteinase 3 protein. (211 aa)
IL17AInterleukin-17A. (153 aa)
COL4A1Collagen type IV alpha 1 chain. (1608 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
COL1A1Collagen type I alpha 1 chain. (1463 aa)
IL13Interleukin 13. (131 aa)
LDLRLow density lipoprotein receptor. (787 aa)
SMAD7Mothers against decapentaplegic homolog. (427 aa)
LOC102190507Uncharacterized protein. (139 aa)
KLF4Kruppel like factor 4. (510 aa)
MMP9Uncharacterized protein. (709 aa)
IL10Interleukin 10. (177 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
ACE2Angiotensin-converting enzyme. (804 aa)
ICAM1Intercellular adhesion molecule 1. (532 aa)
COL17A1Collagen type XVII alpha 1 chain. (1262 aa)
ACTBUncharacterized protein. (375 aa)
CCL11C-C motif chemokine. (97 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (254 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
STAT1Signal transducer and activator of transcription. (834 aa)
SKILc-SKI_SMAD_bind domain-containing protein. (684 aa)
TLR5TIR domain-containing protein; Belongs to the Toll-like receptor family. (871 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (129 aa)
CSF2Granulocyte-macrophage colony stimulating factor. (144 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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