16 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LUM	Lumican. (342 aa)
	PSAT1	Phosphoserine aminotransferase. (370 aa)
	MMP13	Matrix metallopeptidase 13. (472 aa)
	EGFR	Receptor protein-tyrosine kinase. (1208 aa)
	CDK4	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
	PHGDH	D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (533 aa)
	LOC102181743	MFS domain-containing protein. (491 aa)
	YAP1	Yes associated protein 1. (503 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3058 aa)
	SHMT1	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (484 aa)
	ACTB	Uncharacterized protein. (375 aa)
	PSPH	Phosphoserine phosphatase. (225 aa)
	RAD50	Zinc-hook domain-containing protein. (1332 aa)
	SHMT2	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (502 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (396 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ATM	ENSCHIP00000011080	ENSCHIP00000016363	Uncharacterized protein.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.762
ACTB	CDK4	ENSCHIP00000011080	ENSCHIP00000022710	Uncharacterized protein.	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily.	0.824
ACTB	EGFR	ENSCHIP00000011080	ENSCHIP00000022759	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.891
ACTB	MAPK1	ENSCHIP00000011080	ENSCHIP00000000204	Uncharacterized protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.651
ACTB	MMP13	ENSCHIP00000011080	ENSCHIP00000023527	Uncharacterized protein.	Matrix metallopeptidase 13.	0.722
ACTB	MTOR	ENSCHIP00000011080	ENSCHIP00000021872	Uncharacterized protein.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.734
ACTB	YAP1	ENSCHIP00000011080	ENSCHIP00000017099	Uncharacterized protein.	Yes associated protein 1.	0.642
ATM	ACTB	ENSCHIP00000016363	ENSCHIP00000011080	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Uncharacterized protein.	0.762
ATM	CDK4	ENSCHIP00000016363	ENSCHIP00000022710	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily.	0.804
ATM	EGFR	ENSCHIP00000016363	ENSCHIP00000022759	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Receptor protein-tyrosine kinase.	0.599
ATM	MTOR	ENSCHIP00000016363	ENSCHIP00000021872	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.592
ATM	RAD50	ENSCHIP00000016363	ENSCHIP00000003154	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Zinc-hook domain-containing protein.	0.995
CDK4	ACTB	ENSCHIP00000022710	ENSCHIP00000011080	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.824
CDK4	ATM	ENSCHIP00000022710	ENSCHIP00000016363	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.804
CDK4	EGFR	ENSCHIP00000022710	ENSCHIP00000022759	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily.	Receptor protein-tyrosine kinase.	0.404
EGFR	ACTB	ENSCHIP00000022759	ENSCHIP00000011080	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.891
EGFR	ATM	ENSCHIP00000022759	ENSCHIP00000016363	Receptor protein-tyrosine kinase.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.599
EGFR	CDK4	ENSCHIP00000022759	ENSCHIP00000022710	Receptor protein-tyrosine kinase.	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily.	0.404
EGFR	MTOR	ENSCHIP00000022759	ENSCHIP00000021872	Receptor protein-tyrosine kinase.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.541
EGFR	YAP1	ENSCHIP00000022759	ENSCHIP00000017099	Receptor protein-tyrosine kinase.	Yes associated protein 1.	0.825